Q9NYW4 · TA2R5_HUMAN
- ProteinTaste receptor type 2 member 5
- GeneTAS2R5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids299 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Miscellaneous
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | bitter taste receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | taste receptor activity | |
Biological Process | chemosensory behavior | |
Biological Process | detection of chemical stimulus involved in sensory perception of bitter taste |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTaste receptor type 2 member 5
- Short namesT2R5
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NYW4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1 | Extracellular | ||||
Sequence: M | ||||||
Transmembrane | 2-22 | Helical; Name=1 | ||||
Sequence: LSAGLGLLMLVAVVEFLIGLI | ||||||
Topological domain | 23-45 | Cytoplasmic | ||||
Sequence: GNGSLVVWSFREWIRKFNWSSYN | ||||||
Transmembrane | 46-66 | Helical; Name=2 | ||||
Sequence: LIILGLAGCRFLLQWLIILDL | ||||||
Topological domain | 67-82 | Extracellular | ||||
Sequence: SLFPLFQSSRWLRYLS | ||||||
Transmembrane | 83-103 | Helical; Name=3 | ||||
Sequence: IFWVLVSQASLWFATFLSVFY | ||||||
Topological domain | 104-127 | Cytoplasmic | ||||
Sequence: CKKITTFDRPAYLWLKQRAYNLSL | ||||||
Transmembrane | 128-148 | Helical; Name=4 | ||||
Sequence: WCLLGYFIINLLLTVQIGLTF | ||||||
Topological domain | 149-175 | Extracellular | ||||
Sequence: YHPPQGNSSIRYPFESWQYLYAFQLNS | ||||||
Transmembrane | 176-196 | Helical; Name=5 | ||||
Sequence: GSYLPLVVFLVSSGMLIVSLY | ||||||
Topological domain | 197-223 | Cytoplasmic | ||||
Sequence: THHKKMKVHSAGRRDVRAKAHITALKS | ||||||
Transmembrane | 224-244 | Helical; Name=6 | ||||
Sequence: LGCFLLLHLVYIMASPFSITS | ||||||
Topological domain | 245-253 | Extracellular | ||||
Sequence: KTYPPDLTS | ||||||
Transmembrane | 254-274 | Helical; Name=7 | ||||
Sequence: VFIWETLMAAYPSLHSLILIM | ||||||
Topological domain | 275-299 | Cytoplasmic | ||||
Sequence: GIPRVKQTCQKILWKTVCARRCWGP |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_053343 | 20 | in dbSNP:rs2234013 | |||
Sequence: G → S | ||||||
Natural variant | VAR_020203 | 26 | in dbSNP:rs2227264 | |||
Sequence: S → I | ||||||
Natural variant | VAR_034537 | 113 | in dbSNP:rs2234014 | |||
Sequence: P → L | ||||||
Natural variant | VAR_034538 | 167 | in dbSNP:rs34529840 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_024184 | 213 | in dbSNP:rs2234015 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_053344 | 294 | in dbSNP:rs2234016 | |||
Sequence: R → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 320 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082212 | 1-299 | Taste receptor type 2 member 5 | |||
Sequence: MLSAGLGLLMLVAVVEFLIGLIGNGSLVVWSFREWIRKFNWSSYNLIILGLAGCRFLLQWLIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVFYCKKITTFDRPAYLWLKQRAYNLSLWCLLGYFIINLLLTVQIGLTFYHPPQGNSSIRYPFESWQYLYAFQLNSGSYLPLVVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHITALKSLGCFLLLHLVYIMASPFSITSKTYPPDLTSVFIWETLMAAYPSLHSLILIMGIPRVKQTCQKILWKTVCARRCWGP | ||||||
Glycosylation | 155 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9NYW4 | CCL4 P13236 | 3 | EBI-17933167, EBI-2873970 | |
BINARY | Q9NYW4 | RTP2 Q5QGT7 | 3 | EBI-17933167, EBI-10244780 | |
BINARY | Q9NYW4 | SFT2D2 O95562 | 3 | EBI-17933167, EBI-4402330 | |
BINARY | Q9NYW4 | SLC30A2 Q9BRI3 | 3 | EBI-17933167, EBI-8644112 | |
BINARY | Q9NYW4 | TMEM187 Q14656 | 3 | EBI-17933167, EBI-13046724 | |
BINARY | Q9NYW4 | VAMP5 O95183 | 3 | EBI-17933167, EBI-10191195 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)34,505
- Last updated2000-10-01 v1
- ChecksumF85064A07E9018C7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF227132 EMBL· GenBank· DDBJ | AAF43905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY724966 EMBL· GenBank· DDBJ | AAU21159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC004979 EMBL· GenBank· DDBJ | AAS02040.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC069509 EMBL· GenBank· DDBJ | AAH69509.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101586 EMBL· GenBank· DDBJ | AAI01587.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101588 EMBL· GenBank· DDBJ | AAI01589.1 EMBL· GenBank· DDBJ | mRNA |