Q9NYW2 · TA2R8_HUMAN

  • Protein
    Taste receptor type 2 member 8
  • Gene
    TAS2R8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionbitter taste receptor activity
Molecular FunctionG protein-coupled receptor activity
Molecular Functiontaste receptor activity
Biological Processdetection of chemical stimulus involved in sensory perception of bitter taste

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Taste receptor type 2 member 8
  • Short names
    T2R8
  • Alternative names
    • Taste receptor family B member 5 (TRB5)

Gene names

    • Name
      TAS2R8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NYW2
  • Secondary accessions
    • Q4KN29
    • Q645Y2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Extracellular
Transmembrane8-28Helical; Name=1
Topological domain29-50Cytoplasmic
Transmembrane51-71Helical; Name=2
Topological domain72-82Extracellular
Transmembrane83-103Helical; Name=3
Topological domain104-131Cytoplasmic
Transmembrane132-152Helical; Name=4
Topological domain153-184Extracellular
Transmembrane185-205Helical; Name=5
Topological domain206-239Cytoplasmic
Transmembrane240-260Helical; Name=6
Topological domain261-266Extracellular
Transmembrane267-287Helical; Name=7
Topological domain288-309Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_024186308in dbSNP:rs2537817

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 716 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000822271-309Taste receptor type 2 member 8
Glycosylation167N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9NYW2NHERF4 Q86UT5-33EBI-12092809, EBI-12092811

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    35,877
  • Last updated
    2000-10-01 v1
  • Checksum
    5E3D94B726A52413
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF227134
EMBL· GenBank· DDBJ
AAF43907.1
EMBL· GenBank· DDBJ
Genomic DNA
AY724935
EMBL· GenBank· DDBJ
AAU21137.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069084
EMBL· GenBank· DDBJ
AAH69084.1
EMBL· GenBank· DDBJ
mRNA
BC069551
EMBL· GenBank· DDBJ
AAH69551.1
EMBL· GenBank· DDBJ
mRNA
BC096701
EMBL· GenBank· DDBJ
AAH96701.1
EMBL· GenBank· DDBJ
mRNA
BC096735
EMBL· GenBank· DDBJ
AAH96735.1
EMBL· GenBank· DDBJ
mRNA
BC098353
EMBL· GenBank· DDBJ
AAH98353.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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