Q9NYW0 · T2R10_HUMAN
- ProteinTaste receptor type 2 member 10
- GeneTAS2R10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids307 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Miscellaneous
Several bitter taste receptors are expressed in a single taste receptor cell.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | bitter taste receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | taste receptor activity | |
Biological Process | detection of chemical stimulus involved in sensory perception of bitter taste |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTaste receptor type 2 member 10
- Short namesT2R10
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NYW0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-6 | Extracellular | ||||
Sequence: MLRVVE | ||||||
Transmembrane | 7-27 | Helical; Name=1 | ||||
Sequence: GIFIFVVVSESVFGVLGNGFI | ||||||
Topological domain | 28-42 | Cytoplasmic | ||||
Sequence: GLVNCIDCAKNKLST | ||||||
Transmembrane | 43-63 | Helical; Name=2 | ||||
Sequence: IGFILTGLAISRIFLIWIIIT | ||||||
Topological domain | 64-100 | Extracellular | ||||
Sequence: DGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFAT | ||||||
Transmembrane | 101-121 | Helical; Name=3 | ||||
Sequence: SLSIFYFLKIANFSNYIFLWL | ||||||
Topological domain | 122-126 | Cytoplasmic | ||||
Sequence: KSRTN | ||||||
Transmembrane | 127-147 | Helical; Name=4 | ||||
Sequence: MVLPFMIVFLLISSLLNFAYI | ||||||
Topological domain | 148-179 | Extracellular | ||||
Sequence: AKILNDYKTKNDTVWDLNMYKSEYFIKQILLN | ||||||
Transmembrane | 180-200 | Helical; Name=5 | ||||
Sequence: LGVIFFFTLSLITCIFLIISL | ||||||
Topological domain | 201-227 | Cytoplasmic | ||||
Sequence: WRHNRQMQSNVTGLRDSNTEAHVKAMK | ||||||
Transmembrane | 228-248 | Helical; Name=6 | ||||
Sequence: VLISFIILFILYFIGMAIEIS | ||||||
Topological domain | 249-257 | Extracellular | ||||
Sequence: CFTVRENKL | ||||||
Transmembrane | 258-278 | Helical; Name=7 | ||||
Sequence: LLMFGMTTTAIYPWGHSFILI | ||||||
Topological domain | 279-307 | Cytoplasmic | ||||
Sequence: LGNSKLKQASLRVLQQLKCCEKRKNLRVT |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_030009 | 156 | in dbSNP:rs597468 | |||
Sequence: T → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 642 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000082238 | 1-307 | UniProt | Taste receptor type 2 member 10 | |||
Sequence: MLRVVEGIFIFVVVSESVFGVLGNGFIGLVNCIDCAKNKLSTIGFILTGLAISRIFLIWIIITDGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFATSLSIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKTKNDTVWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCIFLIISLWRHNRQMQSNVTGLRDSNTEAHVKAMKVLISFIILFILYFIGMAIEISCFTVRENKLLLMFGMTTTAIYPWGHSFILILGNSKLKQASLRVLQQLKCCEKRKNLRVT | |||||||
Glycosylation | 92 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 158 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 212 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9NYW0 | HERPUD2 Q9BSE4 | 3 | EBI-12963900, EBI-2868124 | |
BINARY | Q9NYW0 | PDCD1LG2 Q9BQ51 | 3 | EBI-12963900, EBI-16427978 | |
BINARY | Q9NYW0 | RTP4 Q96DX8 | 3 | EBI-12963900, EBI-12275482 | |
BINARY | Q9NYW0 | SSMEM1 Q8WWF3 | 3 | EBI-12963900, EBI-17280858 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length307
- Mass (Da)35,365
- Last updated2010-11-02 v3
- Checksum058DD69A55AE71C6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF227136 EMBL· GenBank· DDBJ | AAF43909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY724946 EMBL· GenBank· DDBJ | AAU21148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC006518 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC069089 EMBL· GenBank· DDBJ | AAH69089.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101762 EMBL· GenBank· DDBJ | AAI01763.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101764 EMBL· GenBank· DDBJ | AAI01765.1 EMBL· GenBank· DDBJ | mRNA |