Q9NYB5 · SO1C1_HUMAN
- ProteinSolute carrier organic anion transporter family member 1C1
- GeneSLCO1C1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids712 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463).
Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113).
Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113).
Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463).
Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463).
Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914).
Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113).
Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113).
Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463).
Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463).
Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914).
Catalytic activity
- 3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)
- L-thyroxine(out) = L-thyroxine(in)
- L-thyroxine sulfate(out) = L-thyroxine sulfate(in)
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
90 nM | L-thyroxine | |||||
120 nM | L-thyroxine | |||||
270 nM | L-thyroxine | 6.5 | ||||
180 nM | L-thyroxine | 8.0 | ||||
128 nM | 3,3',5'-triiodo-L-thyronine | |||||
2.6 μM | L-thyroxine sulfate |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
37.8 pmol/min/mg | 6.5 | with L-thyroxine as substrate | |||
22 pmol/min/mg | 8.0 | with L-thyroxine as substrate |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | plasma membrane | |
Molecular Function | bile acid transmembrane transporter activity | |
Molecular Function | organic anion transmembrane transporter activity | |
Molecular Function | sodium-independent organic anion transmembrane transporter activity | |
Molecular Function | thyroid hormone transmembrane transporter activity | |
Biological Process | bile acid and bile salt transport | |
Biological Process | monoatomic ion transport | |
Biological Process | positive regulation of thyroid hormone generation | |
Biological Process | sodium-independent organic anion transport | |
Biological Process | thyroid hormone transport | |
Biological Process | transmembrane transport | |
Biological Process | transport across blood-brain barrier |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier organic anion transporter family member 1C1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NYB5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-43 | Cytoplasmic | ||||
Sequence: MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELK | ||||||
Transmembrane | 44-63 | Helical; Name=1 | ||||
Sequence: VFLCALSFVYFAKALAEGYL | ||||||
Topological domain | 64-82 | Extracellular | ||||
Sequence: KSTITQIERRFDIPSSLVG | ||||||
Transmembrane | 83-103 | Helical; Name=2 | ||||
Sequence: VIDGSFEIGNLLVITFVSYFG | ||||||
Topological domain | 104-109 | Cytoplasmic | ||||
Sequence: AKLHRP | ||||||
Transmembrane | 110-134 | Helical; Name=3 | ||||
Sequence: KIIGAGCVIMGVGTLLIAMPQFFME | ||||||
Topological domain | 135-184 | Extracellular | ||||
Sequence: QYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSS | ||||||
Transmembrane | 185-213 | Helical; Name=4 | ||||
Sequence: SMWIYVFLGNLLRGIGETPIQPLGIAYLD | ||||||
Topological domain | 214-232 | Cytoplasmic | ||||
Sequence: DFASEDNAAFYIGCVQTVA | ||||||
Transmembrane | 233-253 | Helical; Name=5 | ||||
Sequence: IIGPIFGFLLGSLCAKLYVDI | ||||||
Topological domain | 254-271 | Extracellular | ||||
Sequence: GFVNLDHITITPKDPQWV | ||||||
Transmembrane | 272-296 | Helical; Name=6 | ||||
Sequence: GAWWLGYLIAGIISLLAAVPFWYLP | ||||||
Topological domain | 297-348 | Cytoplasmic | ||||
Sequence: KSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKN | ||||||
Transmembrane | 349-370 | Helical; Name=7 | ||||
Sequence: LFGNPVYFLYLCTSTVQFNSLF | ||||||
Topological domain | 371-390 | Extracellular | ||||
Sequence: GMVTYKPKYIEQQYGQSSSR | ||||||
Transmembrane | 391-414 | Helical; Name=8 | ||||
Sequence: ANFVIGLINIPAVALGIFSGGIVM | ||||||
Topological domain | 415-418 | Cytoplasmic | ||||
Sequence: KKFR | ||||||
Transmembrane | 419-442 | Helical; Name=9 | ||||
Sequence: ISVCGAAKLYLGSSVFGYLLFLSL | ||||||
Topological domain | 443-554 | Extracellular | ||||
Sequence: FALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYF | ||||||
Transmembrane | 555-577 | Helical; Name=10 | ||||
Sequence: LVISVITSYTLSLGGIPGYILLL | ||||||
Topological domain | 578-586 | Cytoplasmic | ||||
Sequence: RCIKPQLKS | ||||||
Transmembrane | 587-612 | Helical; Name=11 | ||||
Sequence: FALGIYTLAIRVLAGIPAPVYFGVLI | ||||||
Topological domain | 613-646 | Extracellular | ||||
Sequence: DTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLT | ||||||
Transmembrane | 647-664 | Helical; Name=12 | ||||
Sequence: VILGTVSILLSIAVLFIL | ||||||
Topological domain | 665-712 | Cytoplasmic | ||||
Sequence: KKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 130 | Gain of pH-sensitivity of E1S transport. | ||||
Sequence: Q → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,134 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000191054 | 1-712 | Solute carrier organic anion transporter family member 1C1 | |||
Sequence: MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 476↔506 | |||||
Sequence: CNSRCKCSETKWEPMCGENGITYVSACLAGC | ||||||
Disulfide bond | 482↔502 | |||||
Sequence: CSETKWEPMCGENGITYVSAC | ||||||
Disulfide bond | 491↔523 | |||||
Sequence: CGENGITYVSACLAGCQTSNRSGKNIIFYNCTC | ||||||
Glycosylation | 510 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 520 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 533 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in brain and in Leydig cells in testis (PubMed:12351693, PubMed:35307651).
Localized in nests of Leydig cells (at protein level) (PubMed:12351693).
Expressed in choroid plexus (at protein level) (PubMed:18687783).
Not strongly enriched in cerebral microvessels (PubMed:18687783).
Localized in nests of Leydig cells (at protein level) (PubMed:12351693).
Expressed in choroid plexus (at protein level) (PubMed:18687783).
Not strongly enriched in cerebral microvessels (PubMed:18687783).
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 470-525 | Kazal-like | ||||
Sequence: RALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVG |
Sequence similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q9NYB5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length712
- Mass (Da)78,696
- Last updated2000-10-01 v1
- ChecksumCB6D37AAAA8FA7CD
Q9NYB5-2
- Name2
- Differences from canonical
- 177-225: Missing
Q9NYB5-3
- Name3
- Differences from canonical
- 640-712: HIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL → YQIKSIPASHCYSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
Q9NYB5-4
- Name4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F5H6S4 | F5H6S4_HUMAN | SLCO1C1 | 46 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_045278 | 1-118 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_042882 | 177-225 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 444 | in Ref. 3; BAH14027 | ||||
Sequence: A → T | ||||||
Sequence conflict | 559 | In isoform Q9NYB5-4; in Ref. 3; BAH11737 | ||||
Sequence: S → F | ||||||
Alternative sequence | VSP_045279 | 640-712 | in isoform 3 and isoform 4 | |||
Sequence: HIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL → YQIKSIPASHCYSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK | ||||||
Sequence conflict | 660 | In isoform Q9NYB5-3; in Ref. 3; BAH14027 | ||||
Sequence: T → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF260704 EMBL· GenBank· DDBJ | AAF70338.1 EMBL· GenBank· DDBJ | mRNA | ||
AF205076 EMBL· GenBank· DDBJ | AAG42208.1 EMBL· GenBank· DDBJ | mRNA | ||
AK294333 EMBL· GenBank· DDBJ | BAH11737.1 EMBL· GenBank· DDBJ | mRNA | ||
AK296236 EMBL· GenBank· DDBJ | BAH12289.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303713 EMBL· GenBank· DDBJ | BAH14027.1 EMBL· GenBank· DDBJ | mRNA | ||
AL834209 EMBL· GenBank· DDBJ | CAI46209.1 EMBL· GenBank· DDBJ | mRNA | ||
AC092491 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC022461 EMBL· GenBank· DDBJ | AAH22461.1 EMBL· GenBank· DDBJ | mRNA |