Q9NYB5 · SO1C1_HUMAN

  • Protein
    Solute carrier organic anion transporter family member 1C1
  • Gene
    SLCO1C1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463).
Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113).
Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113).
Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463).
Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463).
Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
90 nML-thyroxine
120 nML-thyroxine
270 nML-thyroxine6.5
180 nML-thyroxine8.0
128 nM3,3',5'-triiodo-L-thyronine
2.6 μML-thyroxine sulfate
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
37.8 pmol/min/mg6.5with L-thyroxine as substrate
22 pmol/min/mg8.0with L-thyroxine as substrate

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionbile acid transmembrane transporter activity
Molecular Functionorganic anion transmembrane transporter activity
Molecular Functionsodium-independent organic anion transmembrane transporter activity
Molecular Functionthyroid hormone transmembrane transporter activity
Biological Processbile acid and bile salt transport
Biological Processmonoatomic ion transport
Biological Processpositive regulation of thyroid hormone generation
Biological Processsodium-independent organic anion transport
Biological Processthyroid hormone transport
Biological Processtransmembrane transport
Biological Processtransport across blood-brain barrier

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier organic anion transporter family member 1C1
  • Alternative names
    • Organic anion transporter 1C1
      (OATP1C1
      )
    • Organic anion transporter F (OATP-F
      )
    • Organic anion transporter polypeptide-related protein 5 (OAT-RP-5; OATP-RP5)
    • Organic anion-transporting polypeptide 14
      (OATP-14
      )
    • Solute carrier family 21 member 14
    • Thyroxine transporter

Gene names

    • Name
      SLCO1C1
    • Synonyms
      OATP14, OATP1C1, OATPF, SLC21A14

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NYB5
  • Secondary accessions
    • B7Z251
    • B7Z3Q3
    • B7Z8P1
    • F5GZD6
    • Q5JPA4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-43Cytoplasmic
Transmembrane44-63Helical; Name=1
Topological domain64-82Extracellular
Transmembrane83-103Helical; Name=2
Topological domain104-109Cytoplasmic
Transmembrane110-134Helical; Name=3
Topological domain135-184Extracellular
Transmembrane185-213Helical; Name=4
Topological domain214-232Cytoplasmic
Transmembrane233-253Helical; Name=5
Topological domain254-271Extracellular
Transmembrane272-296Helical; Name=6
Topological domain297-348Cytoplasmic
Transmembrane349-370Helical; Name=7
Topological domain371-390Extracellular
Transmembrane391-414Helical; Name=8
Topological domain415-418Cytoplasmic
Transmembrane419-442Helical; Name=9
Topological domain443-554Extracellular
Transmembrane555-577Helical; Name=10
Topological domain578-586Cytoplasmic
Transmembrane587-612Helical; Name=11
Topological domain613-646Extracellular
Transmembrane647-664Helical; Name=12
Topological domain665-712Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis130Gain of pH-sensitivity of E1S transport.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,134 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001910541-712Solute carrier organic anion transporter family member 1C1
Glycosylation146N-linked (GlcNAc...) asparagine
Disulfide bond476↔506
Disulfide bond482↔502
Disulfide bond491↔523
Glycosylation510N-linked (GlcNAc...) asparagine
Glycosylation520N-linked (GlcNAc...) asparagine
Glycosylation533N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in brain and in Leydig cells in testis (PubMed:12351693, PubMed:35307651).
Localized in nests of Leydig cells (at protein level) (PubMed:12351693).
Expressed in choroid plexus (at protein level) (PubMed:18687783).
Not strongly enriched in cerebral microvessels (PubMed:18687783).

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain470-525Kazal-like

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9NYB5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    712
  • Mass (Da)
    78,696
  • Last updated
    2000-10-01 v1
  • Checksum
    CB6D37AAAA8FA7CD
MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL

Q9NYB5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9NYB5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 640-712: HIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL → YQIKSIPASHCYSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK

Q9NYB5-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-118: Missing
    • 640-712: HIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL → YQIKSIPASHCYSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F5H6S4F5H6S4_HUMANSLCO1C146

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0452781-118in isoform 4
Alternative sequenceVSP_042882177-225in isoform 2
Sequence conflict444in Ref. 3; BAH14027
Sequence conflict559In isoform Q9NYB5-4; in Ref. 3; BAH11737
Alternative sequenceVSP_045279640-712in isoform 3 and isoform 4
Sequence conflict660In isoform Q9NYB5-3; in Ref. 3; BAH14027

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF260704
EMBL· GenBank· DDBJ
AAF70338.1
EMBL· GenBank· DDBJ
mRNA
AF205076
EMBL· GenBank· DDBJ
AAG42208.1
EMBL· GenBank· DDBJ
mRNA
AK294333
EMBL· GenBank· DDBJ
BAH11737.1
EMBL· GenBank· DDBJ
mRNA
AK296236
EMBL· GenBank· DDBJ
BAH12289.1
EMBL· GenBank· DDBJ
mRNA
AK303713
EMBL· GenBank· DDBJ
BAH14027.1
EMBL· GenBank· DDBJ
mRNA
AL834209
EMBL· GenBank· DDBJ
CAI46209.1
EMBL· GenBank· DDBJ
mRNA
AC092491
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC022461
EMBL· GenBank· DDBJ
AAH22461.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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