Q9NY57 · ST32B_HUMAN

  • Protein
    Serine/threonine-protein kinase 32B
  • Gene
    STK32B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site29-37ATP (UniProtKB | ChEBI)
Binding site52ATP (UniProtKB | ChEBI)
Active site146Proton acceptor

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase 32B
  • EC number
  • Alternative names
    • Yet another novel kinase 2

Gene names

    • Name
      STK32B
    • Synonyms
      YANK2
    • ORF names
      UNQ3003/PRO9744

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NY57
  • Secondary accessions
    • Q6UXH3
    • Q8IY14

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04116635in a metastatic melanoma sample; somatic mutation
Natural variantVAR_025899198in dbSNP:rs3733182
Natural variantVAR_041167244in dbSNP:rs35207488
Natural variantVAR_041168310in dbSNP:rs56259884
Natural variantVAR_041169342in dbSNP:rs55961955

Variants

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The viewer provides 604 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002324131-414UniProtSerine/threonine-protein kinase 32B
Modified residue (large scale data)378PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain23-283Protein kinase
Region374-396Disordered

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9NY57-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    414
  • Mass (Da)
    47,883
  • Last updated
    2000-10-01 v1
  • Checksum
    8FCD58A67EF09B0E
MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVREEFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS

Q9NY57-2

  • Name
    2
  • Note
    It is unsure whether Met-1 or Met-3 is the initiator.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6R9Y2D6R9Y2_HUMANSTK32B51
E9PCC0E9PCC0_HUMANSTK32B337

Sequence caution

The sequence AAQ88719.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0519971-47in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ250839
EMBL· GenBank· DDBJ
CAB76471.1
EMBL· GenBank· DDBJ
mRNA
AY358353
EMBL· GenBank· DDBJ
AAQ88719.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC038238
EMBL· GenBank· DDBJ
AAH38238.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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