Q9NX76 · CKLF6_HUMAN

  • Protein
    CKLF-like MARVEL transmembrane domain-containing protein 6
  • Gene
    CMTM6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentazurophil granule membrane
Cellular Componentearly endosome membrane
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentrecycling endosome membrane
Cellular Componentspecific granule membrane
Biological Processendocytic recycling
Biological Processprotein transport
Biological Processregulation of protein stability

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    CKLF-like MARVEL transmembrane domain-containing protein 6
  • Alternative names
    • Chemokine-like factor superfamily member 6

Gene names

    • Name
      CMTM6
    • Synonyms
      CKLFSF6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NX76
  • Secondary accessions
    • Q6IAC4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein
Note: Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-39Cytoplasmic
Transmembrane40-60Helical
Topological domain61-67Extracellular
Transmembrane68-88Helical
Topological domain89-106Cytoplasmic
Transmembrane107-127Helical
Topological domain128-134Extracellular
Transmembrane135-155Helical
Topological domain156-183Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_06199891in dbSNP:rs35574803

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 184 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue1UniProtN-acetylmethionine
ChainPRO_00001861071-183UniProtCKLF-like MARVEL transmembrane domain-containing protein 6
Modified residue (large scale data)7PRIDEPhosphotyrosine
Modified residue8UniProtPhosphoserine
Modified residue (large scale data)8PRIDEPhosphoserine
Modified residue171UniProtPhosphothreonine
Modified residue (large scale data)178PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the leukocytes, placenta and testis.

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-160MARVEL

Sequence similarities

Belongs to the chemokine-like factor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    183
  • Mass (Da)
    20,419
  • Last updated
    2000-10-01 v1
  • Checksum
    43DAEB652A6B50B4
MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEPLNA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF479261
EMBL· GenBank· DDBJ
AAN73039.1
EMBL· GenBank· DDBJ
mRNA
AK000403
EMBL· GenBank· DDBJ
BAA91141.1
EMBL· GenBank· DDBJ
mRNA
CR457231
EMBL· GenBank· DDBJ
CAG33512.1
EMBL· GenBank· DDBJ
mRNA
CH471055
EMBL· GenBank· DDBJ
EAW64429.1
EMBL· GenBank· DDBJ
Genomic DNA
BC002797
EMBL· GenBank· DDBJ
AAH02797.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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