Q9NX61 · T161A_HUMAN

  • Protein
    Transmembrane protein 161A
  • Gene
    TMEM161A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Biological Processcellular response to oxidative stress
Biological Processcellular response to UV
Biological Processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Biological Processpositive regulation of DNA repair
Biological Processresponse to retinoic acid

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein 161A
  • Alternative names
    • Adaptive response to oxidative stress protein 29 (AROS-29)

Gene names

    • Name
      TMEM161A
    • ORF names
      UNQ582/PRO1152

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NX61
  • Secondary accessions
    • B3KUE0
    • G5E9M6
    • Q7L2Y1

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-98Extracellular
Transmembrane99-119Helical
Topological domain120-134Cytoplasmic
Transmembrane135-155Helical
Topological domain156-166Extracellular
Transmembrane167-187Helical
Topological domain188-224Cytoplasmic
Transmembrane225-245Helical
Topological domain246-263Extracellular
Transmembrane264-284Helical
Topological domain285-304Cytoplasmic
Transmembrane305-325Helical
Topological domain326-370Extracellular
Transmembrane371-391Helical
Topological domain392-449Cytoplasmic
Transmembrane450-470Helical
Topological domain471-479Extracellular

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03653785in a breast cancer sample; somatic mutation

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 570 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_000028808429-479Transmembrane protein 161A
Glycosylation34N-linked (GlcNAc...) asparagine
Modified residue69Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Induction

Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9NX61GPR37 O153542EBI-6138599, EBI-15639515

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q9NX61-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    479
  • Mass (Da)
    53,602
  • Last updated
    2000-10-01 v1
  • Checksum
    4DEA8A1C04CCA33D
MAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPSEEELRALAGKPRPRGRKERWANGLSEEKPLSVPRDAPFQLETCPLTTVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTVTFSIKMFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLASMTQNLEPLLKKQGWDWALPVAKLAIRVGLAVVGSVLGAFLTFPGLRLAQTHRDALTMSEDRPMLQFLLHTSFLSPLFILWLWTKPIARDFLHQPPFGETRFSLLSDSAFDSGRLWLLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPAPLLSPDPSSASAAPIGSGEDEVQQTAARIAGALGGLLTPLFLRGVLAYLIWWTAACQLLASLFGLYFHQHLAGS

Q9NX61-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
K7EJK6K7EJK6_HUMANTMEM161A40
V9GYP8V9GYP8_HUMANTMEM161A61
U3KQT6U3KQT6_HUMANTMEM161A325
K7EKY7K7EKY7_HUMANTMEM161A194
K7EQ34K7EQ34_HUMANTMEM161A315
K7EPA3K7EPA3_HUMANTMEM161A454
K7EQE7K7EQE7_HUMANTMEM161A145

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_04604296-198in isoform 2
Sequence conflict455in Ref. 2; BAG53402

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY358088
EMBL· GenBank· DDBJ
AAQ88455.1
EMBL· GenBank· DDBJ
mRNA
AK000429
EMBL· GenBank· DDBJ
BAA91159.1
EMBL· GenBank· DDBJ
mRNA
AK096964
EMBL· GenBank· DDBJ
BAG53402.1
EMBL· GenBank· DDBJ
mRNA
AC002126
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471106
EMBL· GenBank· DDBJ
EAW84787.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005210
EMBL· GenBank· DDBJ
AAH05210.1
EMBL· GenBank· DDBJ
mRNA
BC016478
EMBL· GenBank· DDBJ
AAH16478.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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