Q9NSB2 · KRT84_HUMAN

  • Protein
    Keratin, type II cuticular Hb4
  • Gene
    KRT84
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentkeratin filament
Molecular Functionstructural constituent of cytoskeleton
Molecular Functionstructural constituent of skin epidermis
Biological Processhair follicle development
Biological Processintermediate filament organization
Biological Processkeratinization
Biological Processnail development
Biological Processregulation of keratinocyte differentiation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Keratin, type II cuticular Hb4
  • Alternative names
    • Keratin-84 (K84)
    • Type II hair keratin Hb4
    • Type-II keratin Kb24

Gene names

    • Name
      KRT84
    • Synonyms
      KRTHB4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NSB2
  • Secondary accessions
    • B2RA43
    • Q6ISB0
    • Q701L6

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_018122184in dbSNP:rs1613931
Natural variantVAR_030734198in dbSNP:rs1732301
Natural variantVAR_018123206in dbSNP:rs2245203
Natural variantVAR_018124446in dbSNP:rs951773
Natural variantVAR_030735497in dbSNP:rs7297413

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 814 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000637001-600Keratin, type II cuticular Hb4

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the hair follicles.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-165Head
Domain165-476IF rod
Region166-200Coil 1A
Region201-210Linker 1
Region211-311Coil 1B
Region312-328Linker 12
Region329-472Coil 2
Region473-600Tail

Sequence similarities

Belongs to the intermediate filament family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    600
  • Mass (Da)
    64,842
  • Last updated
    2010-11-02 v2
  • Checksum
    5266B0C4E5AE13F1
MSCRSYRVSSGHRVGNFSSCSAMTPQNLNRFRANSVSCWSGPGFRGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVGLGPRADSCVGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLSRGGVTFSGSSSVCATSGVLASCGPSLGGARVAPATGDLLSTGTRSGSMLISEACVPSVPCPLPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict73in Ref. 5; CAF31524
Sequence conflict159in Ref. 2; BAG36740
Sequence conflict177in Ref. 5; CAF31524
Sequence conflict459in Ref. 2; BAG36740
Sequence conflict548in Ref. 5; CAF31524

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y19209
EMBL· GenBank· DDBJ
CAB76829.1
EMBL· GenBank· DDBJ
Genomic DNA
AK314030
EMBL· GenBank· DDBJ
BAG36740.1
EMBL· GenBank· DDBJ
mRNA
AC078865
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC069647
EMBL· GenBank· DDBJ
AAH69647.1
EMBL· GenBank· DDBJ
mRNA
AJ628420
EMBL· GenBank· DDBJ
CAF31524.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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