Q9NS28 · RGS18_HUMAN

  • Protein
    Regulator of G-protein signaling 18
  • Gene
    RGS18
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionGTPase activator activity
Molecular FunctionGTPase activity
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processnegative regulation of signal transduction
Biological Processregulation of G protein-coupled receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Regulator of G-protein signaling 18
  • Short names
    RGS18

Gene names

    • Name
      RGS18
    • Synonyms
      RGS13

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NS28
  • Secondary accessions
    • B2RD23

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

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The viewer provides 323 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00002042271-235UniProtRegulator of G-protein signaling 18
Modified residue (large scale data)28PRIDEPhosphoserine
Modified residue49UniProtPhosphoserine
Modified residue (large scale data)49PRIDEPhosphoserine
Modified residue (large scale data)76PRIDEPhosphoserine
Modified residue216UniProtPhosphoserine
Modified residue218UniProtPhosphoserine
Modified residue (large scale data)218PRIDEPhosphoserine

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Tissue specificity

Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q9NS28Gnao1 P592152EBI-15933052, EBI-8071125

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain86-202RGS

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    235
  • Mass (Da)
    27,582
  • Last updated
    2000-10-01 v1
  • Checksum
    973ABDE8EC7DE3D5
METTLLFFSQINMCESKEKTFFKLIHGSGKEETSKEAKIRAKEKRNRLSLLVQKPEFHEDTRSSRSGHLAKETRVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict226-227in Ref. 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF076642
EMBL· GenBank· DDBJ
AAF80227.1
EMBL· GenBank· DDBJ
mRNA
AF268036
EMBL· GenBank· DDBJ
AAK58589.1
EMBL· GenBank· DDBJ
mRNA
AL596342
EMBL· GenBank· DDBJ
CAH71160.1
EMBL· GenBank· DDBJ
Genomic DNA
AL513175
EMBL· GenBank· DDBJ
CAH71160.1
EMBL· GenBank· DDBJ
Genomic DNA
AK315377
EMBL· GenBank· DDBJ
BAG37770.1
EMBL· GenBank· DDBJ
mRNA
AL513175
EMBL· GenBank· DDBJ
CAH70529.1
EMBL· GenBank· DDBJ
Genomic DNA
AL596342
EMBL· GenBank· DDBJ
CAH70529.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471067
EMBL· GenBank· DDBJ
EAW91223.1
EMBL· GenBank· DDBJ
Genomic DNA
BC020632
EMBL· GenBank· DDBJ
AAH20632.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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