Q9NR64 · KLHL1_HUMAN
- ProteinKelch-like protein 1
- GeneKLHL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids748 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May play a role in organizing the actin cytoskeleton of the brain cells.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | dendrite | |
Cellular Component | neuronal cell body | |
Molecular Function | actin binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | adult walking behavior | |
Biological Process | cerebellar Purkinje cell layer development | |
Biological Process | dendrite development |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKelch-like protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NR64
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,049 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000119099 | 1-748 | Kelch-like protein 1 | |||
Sequence: MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in brain.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9NR64 | CUL3 Q13618 | 3 | EBI-6426228, EBI-456129 | |
BINARY | Q9NR64 | NUDCD3 Q8IVD9 | 2 | EBI-6426228, EBI-744342 | |
BINARY | Q9NR64 | VHL P40337-2 | 3 | EBI-6426228, EBI-12157263 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 22-93 | Disordered | ||||
Sequence: FSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLN | ||||||
Compositional bias | 45-93 | Polar residues | ||||
Sequence: SFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLN | ||||||
Region | 151-182 | Disordered | ||||
Sequence: EPDNSSQATGEGCGHRLSSTGHSMTPQSDLDS | ||||||
Domain | 212-279 | BTB | ||||
Sequence: CDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKE | ||||||
Repeat | 460-506 | Kelch 1 | ||||
Sequence: TLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDD | ||||||
Repeat | 507-553 | Kelch 2 | ||||
Sequence: KLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG | ||||||
Repeat | 555-600 | Kelch 3 | ||||
Sequence: IYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG | ||||||
Repeat | 601-647 | Kelch 4 | ||||
Sequence: KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDG | ||||||
Repeat | 649-700 | Kelch 5 | ||||
Sequence: LYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGD | ||||||
Repeat | 701-747 | Kelch 6 | ||||
Sequence: RLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQ |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length748
- Mass (Da)82,680
- Last updated2000-10-01 v1
- ChecksumC11C43D8282F9FF9
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F5H1J3 | F5H1J3_HUMAN | KLHL1 | 687 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 45-93 | Polar residues | ||||
Sequence: SFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF252283 EMBL· GenBank· DDBJ | AAF81719.1 EMBL· GenBank· DDBJ | mRNA | ||
AF252279 EMBL· GenBank· DDBJ | AAF81716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB040923 EMBL· GenBank· DDBJ | BAA96014.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK291435 EMBL· GenBank· DDBJ | BAF84124.1 EMBL· GenBank· DDBJ | mRNA | ||
AL160391 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL162378 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL353738 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL356384 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471093 EMBL· GenBank· DDBJ | EAW80503.1 EMBL· GenBank· DDBJ | Genomic DNA |