Q9NR34 · MA1C1_HUMAN

  • Protein
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
  • Gene
    MAN1C1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce first Man8GlcNAc2 then Man6GlcNAc and a small amount of Man5GlcNAc.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Activity regulation

Inhibited by both 1-deoxymannojirimycin and kifunensine.

Pathway

Protein modification; protein glycosylation.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site499Proton donor
Binding site610Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular exosome
Cellular ComponentGolgi membrane
Molecular Functioncalcium ion binding
Molecular Functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Processcarbohydrate metabolic process
Biological ProcessGolgi apparatus mannose trimming
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
  • EC number
  • Alternative names
    • HMIC
    • Mannosidase alpha class 1C member 1
    • Processing alpha-1,2-mannosidase IC (Alpha-1,2-mannosidase IC)

Gene names

    • Name
      MAN1C1
    • Synonyms
      MAN1A3, MAN1C

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NR34
  • Secondary accessions
    • A6NNE2
    • B2RNP2
    • Q9Y545

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-22Cytoplasmic
Transmembrane23-43Helical; Signal-anchor for type II membrane protein
Topological domain44-630Lumenal

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 692 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data), glycosylation, disulfide bond.

TypeIDPosition(s)SourceDescription
ChainPRO_00002103151-630UniProtMannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Modified residue164UniProtPhosphoserine
Modified residue (large scale data)164PRIDEPhosphoserine
Glycosylation250UniProtN-linked (GlcNAc...) asparagine
Disulfide bond453↔485UniProt
Glycosylation618UniProtN-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9NR34FARS2 O953633EBI-7260764, EBI-2513774
BINARY Q9NR34MYG1 Q9HB073EBI-7260764, EBI-709754

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region74-140Disordered
Compositional bias77-91Pro residues

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    70,911
  • Last updated
    2000-10-01 v1
  • Checksum
    80FFC71EFB36552A
MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDSSGRAWGRH

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A6NGN6A6NGN6_HUMANMAN1C1401
B1AJZ5B1AJZ5_HUMANMAN1C1450

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias77-91Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF261655
EMBL· GenBank· DDBJ
AAF97058.1
EMBL· GenBank· DDBJ
mRNA
AL020996
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL031280
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC137017
EMBL· GenBank· DDBJ
AAI37018.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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