Q9NQW1 · SC31B_HUMAN
- ProteinProtein transport protein Sec31B
- GeneSEC31B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1179 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | COPII vesicle coat | |
Cellular Component | endoplasmic reticulum exit site | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | vesicle coat | |
Molecular Function | structural molecule activity | |
Biological Process | COPII-coated vesicle cargo loading | |
Biological Process | endoplasmic reticulum organization | |
Biological Process | protein transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein transport protein Sec31B
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NQW1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_033228 | 89 | in dbSNP:rs3763695 | |||
Sequence: V → A | ||||||
Natural variant | VAR_033229 | 100 | in dbSNP:rs7074707 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_033230 | 129 | in dbSNP:rs3793706 | |||
Sequence: L → F | ||||||
Natural variant | VAR_033231 | 332 | in dbSNP:rs2295774 | |||
Sequence: S → A | ||||||
Natural variant | VAR_033232 | 372 | in dbSNP:rs2295772 | |||
Sequence: P → S | ||||||
Natural variant | VAR_053415 | 433 | in dbSNP:rs2295771 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_053416 | 478 | in dbSNP:rs11819496 | |||
Sequence: R → T | ||||||
Natural variant | VAR_033233 | 527 | in dbSNP:rs17113157 | |||
Sequence: S → R | ||||||
Natural variant | VAR_033234 | 1169 | in dbSNP:rs2298075 | |||
Sequence: A → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,319 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000295153 | 1-1179 | Protein transport protein Sec31B | |||
Sequence: MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHRGVLSALSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNVTHILSSGKEPVIAQKQKHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSAASFNGWISLYSVMGRSWEVQHMRQADKISSSFSKGQPLPPLQVPEQVAQAPLIPPLKKPPKWIRRPTGVSFAFGGKLVTFGLPSTPAHLVPQPCPRLVFISQVTTESEFLMRSAELQEALGSGNLLNYCQNKSQQALLQSEKMLWQFLKVTLEQDSRMKFLKLLGYSKDELQKKVATWLKSDVGLGESPQPKGNDLNSDRQQAFCSQASKHTTKEASASSAFFDELVPQNMTPWEIPITKDIDGLLSQALLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYLAKKKTKISSLLACVVQKNWKDVVCTCSLKNWREALALLLTYSGTEKFPELCDMLGTRMEQEGSRALTSEARLCYVCSGSVERLVECWAKCHQALSPMALQDLMEKVMVLNRSLEQLRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRLFHAQGSAVLGQQSPPFPFPRIVVGATLHSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGAPCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPPAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGELSLQLQHLPPEKMERKELPPEHQSLKSSFEALLQRCSLSATDLKTKRKLEEAAQRLEYLYEKLCEGTLSPHVVAGLHEVARCVDAGSFEQGLAVHAQVAGCSSFSEVSSFMPILKAVLIIAHKLLV |
Post-translational modification
Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).
Gene expression databases
Organism-specific databases
Interaction
Subunit
COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity).
Interacts with SEC31A
Interacts with SEC31A
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 17-56 | WD 1 | ||||
Sequence: ASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLD | ||||||
Repeat | 67-110 | WD 2 | ||||
Sequence: SRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNVTHILSSGK | ||||||
Repeat | 119-159 | WD 3 | ||||
Sequence: KHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMT | ||||||
Repeat | 166-206 | WD 4 | ||||
Sequence: QPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIK | ||||||
Repeat | 209-254 | WD 5 | ||||
Sequence: DHSNRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLK | ||||||
Repeat | 258-298 | WD 6 | ||||
Sequence: SHSRGILSVSWSQADAELLLTSAKDSQILCRNLGSSEVVYK | ||||||
Repeat | 301-341 | WD 7 | ||||
Sequence: TQSSWCFDVQWCPRDPSVFSAASFNGWISLYSVMGRSWEVQ | ||||||
Repeat | 391-422 | WD 8; interaction with SEC13 | ||||
Sequence: SFAFGGKLVTFGLPSTPAHLVPQPCPRLVFIS | ||||||
Region | 812-856 | Disordered | ||||
Sequence: TSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGP | ||||||
Compositional bias | 825-851 | Pro residues | ||||
Sequence: VPTPSPRPRVFTPQSSPAMPLAPSHPS |
Sequence similarities
Belongs to the WD repeat SEC31 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q9NQW1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsSEC31B-F
- Length1,179
- Mass (Da)128,697
- Last updated2000-10-01 v1
- Checksum88C591B060643A5D
Q9NQW1-2
- Name2
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Q9NQW1-3
- Name3
Q9NQW1-4
- Name4
- SynonymsSEC31B-t
Q9NQW1-5
- Name5
- Differences from canonical
- 165-165: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_026757 | 69-85 | in isoform 3 | |||
Sequence: FHKLVWGSFGSGLLESS → ATSWLQGPAILKSSLGI | ||||||
Alternative sequence | VSP_026758 | 86-1179 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026759 | 165 | in isoform 2 and isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026760 | 349 | in isoform 2 | |||
Sequence: I → V | ||||||
Alternative sequence | VSP_026761 | 350-1179 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026762 | 470-482 | in isoform 4 | |||
Sequence: KVTLEQDSRMKFL → KPARDSSGARR | ||||||
Alternative sequence | VSP_026763 | 483-1179 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 805 | in Ref. 2; CAB45735 | ||||
Sequence: A → V | ||||||
Compositional bias | 825-851 | Pro residues | ||||
Sequence: VPTPSPRPRVFTPQSSPAMPLAPSHPS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF274863 EMBL· GenBank· DDBJ | AAF78243.1 EMBL· GenBank· DDBJ | mRNA | ||
AL080141 EMBL· GenBank· DDBJ | CAB45735.1 EMBL· GenBank· DDBJ | mRNA | ||
BX640914 EMBL· GenBank· DDBJ | CAE45955.1 EMBL· GenBank· DDBJ | mRNA | ||
AL133352 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC034946 EMBL· GenBank· DDBJ | AAH34946.1 EMBL· GenBank· DDBJ | mRNA | ||
BC044569 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC144313 EMBL· GenBank· DDBJ | AAI44314.1 EMBL· GenBank· DDBJ | mRNA |