Q9NQA3 · WASH6_HUMAN

  • Protein
    WAS protein family homolog 6
  • Gene
    WASH6P
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Miscellaneous

WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949).
It is therefore difficult to determine which gene is functional or not. The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes

Caution

The WASH6P N-terminus differs from WASH3P for which it is shown to be required for the WASH complex assembly. Hence is association within the WASH complex is ambiguous. However, WASH6P retains the regions implicated in interaction with WASHC2 and conferring in vitro NPF activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentearly endosome
Cellular Componentearly endosome membrane
Cellular Componentrecycling endosome
Cellular Componentrecycling endosome membrane
Cellular ComponentWASH complex
Molecular Functionactin binding
Molecular Functionalpha-tubulin binding
Molecular Functiongamma-tubulin binding
Biological ProcessArp2/3 complex-mediated actin nucleation
Biological Processendocytic recycling
Biological Processendosomal transport
Biological Processexocytosis
Biological Processregulation of Arp2/3 complex-mediated actin nucleation
Biological Processretrograde transport, endosome to Golgi

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    WAS protein family homolog 6
  • Alternative names
    • Protein FAM39A

Gene names

    • Name
      WASH6P
    • Synonyms
      CXYorf1, FAM39A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NQA3
  • Secondary accessions
    • A6NGF1
    • Q8N305

Proteomes

Organism-specific databases

Subcellular Location

Note: Localization to the endosome membrane is mediated via its interaction with WASHC2.

Keywords

Disease & Variants

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00003445301-447UniProtWAS protein family homolog 6
Modified residue (large scale data)199PRIDEPhosphoserine
Modified residue (large scale data)201PRIDEPhosphoserine
Modified residue (large scale data)325PRIDEPhosphoserine
Modified residue327UniProtPhosphoserine
Modified residue (large scale data)327PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts (via WHD1 region) with WASHC2C; the interaction is direct (By similarity).
View interactors in UniProtKB
View CPX-1171 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-42Disordered
Region1-149WHD1
Compositional bias12-42Polar residues
Region279-389Disordered
Compositional bias282-310Pro residues
Region331-447VCA
Domain343-365WH2
Compositional bias361-380Basic and acidic residues
Region403-447Disordered

Sequence similarities

Belongs to the WASH1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    447
  • Mass (Da)
    47,990
  • Last updated
    2010-01-19 v3
  • Checksum
    7B1217DC3CF9DDAA
MAFHEMQAHKNALGTSGEQQAADITGPTPHQGGWKQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPSIANDLMYSADLGPGIAPSAPGTIPELPTFHTEVAEPLKADLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDGSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKKKQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPVPPPQQPQAEEDEDDWES

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7I2YQU6A0A7I2YQU6_HUMANWASH6P478

Sequence caution

The sequence CAB96818.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-42Polar residues
Compositional bias282-310Pro residues
Compositional bias361-380Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ271736
EMBL· GenBank· DDBJ
CAB96818.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CR595583
EMBL· GenBank· DDBJ
-mRNA No translation available.

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Disclaimer

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