The increase in TNF-alpha during nonalcoholic fatty liver disease promotes the activation of the NLRC4 inflammasome which increases the production of IL-18 and IL-1beta and triggers pyroptosis.
analysis of a subset of inflammasome receptors including NLRP3 NLRC4 and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck
Genetic analysis of Chromobacterium violaceum infection revealed that the TTSS needle protein CprI can stimulate NLRC4 inflammasome activation in human macrophages
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