The structure revealed that the helical architecture of the NLRC4(CARD) filament is essentially identical to that of the downstream filament assembled by the CARD of caspase-1 (casp1(CARD)) but deviates from the split washer-like assembly of the NAIP.NLRC4 oligomer.
cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors but not with Ipaf lacking the LRR domain.
Genetic analysis of Chromobacterium violaceum infection revealed that the TTSS needle protein CprI can stimulate NLRC4 inflammasome activation in human macrophages
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.