Q9NP99 · TREM1_HUMAN
- ProteinTriggering receptor expressed on myeloid cells 1
- GeneTREM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids234 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102).
Isoform 2
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | receptor decoy activity | |
Molecular Function | scaffold protein binding | |
Molecular Function | signaling receptor activity | |
Molecular Function | transmembrane signaling receptor activity | |
Biological Process | adaptive immune response | |
Biological Process | humoral immune response | |
Biological Process | innate immune response | |
Biological Process | intracellular signal transduction | |
Biological Process | neutrophil chemotaxis | |
Biological Process | neutrophil-mediated killing of gram-negative bacterium |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTriggering receptor expressed on myeloid cells 1
- Short namesTREM-1
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NP99
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Cell membrane ; Single-pass type I membrane protein
Note: Recruited to lipid rafts when activated.
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 21-205 | Extracellular | ||||
Sequence: ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFN | ||||||
Transmembrane | 206-226 | Helical | ||||
Sequence: IVILLAGGFLSKSLVFSVLFA | ||||||
Topological domain | 227-234 | Cytoplasmic | ||||
Sequence: VTLRSFVP |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_019333 | 25 | in dbSNP:rs2234237 | |||
Sequence: T → S | ||||||
Natural variant | VAR_035525 | 97 | in a breast cancer sample; somatic mutation | |||
Sequence: R → S | ||||||
Natural variant | VAR_049949 | 135 | in dbSNP:rs34727391 | |||
Sequence: K → T | ||||||
Natural variant | VAR_033624 | 214 | in dbSNP:rs2234245 | |||
Sequence: F → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 303 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MRKTRLWGLLWMLFVSELRA | ||||||
Chain | PRO_0000014986 | 21-234 | Triggering receptor expressed on myeloid cells 1 | |||
Sequence: ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP | ||||||
Disulfide bond | 41↔113 | |||||
Sequence: CDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQC | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 191 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 194 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849).
Expression is associated with a mature stage of myeloid development (PubMed:11922939).
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
Expression is associated with a mature stage of myeloid development (PubMed:11922939).
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
Induction
Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-134 | Ig-like V-type | ||||
Sequence: EEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVT |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q9NP99-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length234
- Mass (Da)26,387
- Last updated2000-10-01 v1
- ChecksumAA114696E35D4D45
Q9NP99-2
- Name2
- SynonymsTREM-1sv, sTREM1
Q9NP99-3
- Name3
- Differences from canonical
- 201-234: VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP → YSFQVPGPLVWTLSPLFPSLCAERM
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
K7EKM5 | K7EKM5_HUMAN | TREM1 | 250 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 35 | in Ref. 3; AAL74018 | ||||
Sequence: Q → K | ||||||
Alternative sequence | VSP_010790 | 138-150 | in isoform 2 | |||
Sequence: SGTPGSNENSTQN → RCSTLSFSWLVDS | ||||||
Alternative sequence | VSP_010791 | 151-234 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053939 | 201-234 | in isoform 3 | |||
Sequence: VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP → YSFQVPGPLVWTLSPLFPSLCAERM |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF196329 EMBL· GenBank· DDBJ | AAF71694.1 EMBL· GenBank· DDBJ | mRNA | ||
AF287008 EMBL· GenBank· DDBJ | AAF90197.1 EMBL· GenBank· DDBJ | mRNA | ||
AY074783 EMBL· GenBank· DDBJ | AAL74018.1 EMBL· GenBank· DDBJ | mRNA | ||
AK301519 EMBL· GenBank· DDBJ | BAG63024.1 EMBL· GenBank· DDBJ | mRNA | ||
AL391903 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC017773 EMBL· GenBank· DDBJ | AAH17773.1 EMBL· GenBank· DDBJ | mRNA | ||
AK223264 EMBL· GenBank· DDBJ | BAD96984.1 EMBL· GenBank· DDBJ | mRNA |