Q9NP99 · TREM1_HUMAN

  • Protein
    Triggering receptor expressed on myeloid cells 1
  • Gene
    TREM1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Isoform 1

Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102).

Isoform 2

Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand.

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functionreceptor decoy activity
Molecular Functionscaffold protein binding
Molecular Functionsignaling receptor activity
Molecular Functiontransmembrane signaling receptor activity
Biological Processadaptive immune response
Biological Processhumoral immune response
Biological Processinnate immune response
Biological Processintracellular signal transduction
Biological Processneutrophil chemotaxis
Biological Processneutrophil-mediated killing of gram-negative bacterium

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triggering receptor expressed on myeloid cells 1
  • Short names
    TREM-1
  • Alternative names
    • Triggering receptor expressed on monocytes 1
  • CD Antigen Name
    • CD354

Gene names

    • Name
      TREM1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NP99
  • Secondary accessions
    • B4DWG2
    • K7EJW1
    • Q53FL8
    • Q5T2C9
    • Q86YU1

Proteomes

Organism-specific databases

Subcellular Location

Isoform 1

Cell membrane
; Single-pass type I membrane protein
Note: Recruited to lipid rafts when activated.

Isoform 2

Secreted

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain21-205Extracellular
Transmembrane206-226Helical
Topological domain227-234Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_01933325in dbSNP:rs2234237
Natural variantVAR_03552597in a breast cancer sample; somatic mutation
Natural variantVAR_049949135in dbSNP:rs34727391
Natural variantVAR_033624214in dbSNP:rs2234245

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 303 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000001498621-234Triggering receptor expressed on myeloid cells 1
Disulfide bond41↔113
Glycosylation146N-linked (GlcNAc...) asparagine
Glycosylation191N-linked (GlcNAc...) asparagine
Glycosylation194N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849).
Expression is associated with a mature stage of myeloid development (PubMed:11922939).
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.

Induction

Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Monomer (PubMed:29568119).
Homomultimer; when activated (PubMed:29568119).
Interacts with TYROBP/DAP12 (PubMed:10799849, PubMed:15351648).
Interacts with TLR4 (PubMed:17098818, PubMed:21393102).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-134Ig-like V-type

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q9NP99-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    234
  • Mass (Da)
    26,387
  • Last updated
    2000-10-01 v1
  • Checksum
    AA114696E35D4D45
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP

Q9NP99-2

  • Name
    2
  • Synonyms
    TREM-1sv, sTREM1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9NP99-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 201-234: VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP → YSFQVPGPLVWTLSPLFPSLCAERM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
K7EKM5K7EKM5_HUMANTREM1250

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict35in Ref. 3; AAL74018
Alternative sequenceVSP_010790138-150in isoform 2
Alternative sequenceVSP_010791151-234in isoform 2
Alternative sequenceVSP_053939201-234in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF196329
EMBL· GenBank· DDBJ
AAF71694.1
EMBL· GenBank· DDBJ
mRNA
AF287008
EMBL· GenBank· DDBJ
AAF90197.1
EMBL· GenBank· DDBJ
mRNA
AY074783
EMBL· GenBank· DDBJ
AAL74018.1
EMBL· GenBank· DDBJ
mRNA
AK301519
EMBL· GenBank· DDBJ
BAG63024.1
EMBL· GenBank· DDBJ
mRNA
AL391903
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC017773
EMBL· GenBank· DDBJ
AAH17773.1
EMBL· GenBank· DDBJ
mRNA
AK223264
EMBL· GenBank· DDBJ
BAD96984.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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