Q9NJI5 · Q9NJI5_LEITA
- ProteinHypoxanthine phosphoribosyltransferase
- Genehgprt
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids210 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
Cofactor
Pathway
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 126 | GMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 127 | GMP (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 129 | GMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 130 | GMP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 131 | GMP (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 133 | GMP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 157 | GMP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 178 | GMP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 179 | GMP (UniProtKB | ChEBI) | ||||
Sequence: V |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypoxanthine phosphoribosyltransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > lizard Leishmania
Accessions
- Primary accessionQ9NJI5
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-182 | Phosphoribosyltransferase | ||||
Sequence: YKDFHLTADNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGSGVETSGQVRMLLDVRDSVENRHIMLVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPHAFVIGY |
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length210
- Mass (Da)23,397
- Last updated2000-10-01 v1
- Checksum643042423F95054D
Keywords
- Technical term