Q9NHX7 · Q9NHX7_DROME
- ProteinProteasome subunit beta
- GeneProsbeta5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids282 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 74 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | proteasome complex | |
Cellular Component | proteasome core complex | |
Cellular Component | proteasome core complex, beta-subunit complex | |
Molecular Function | endopeptidase activity | |
Molecular Function | threonine-type endopeptidase activity | |
Biological Process | centrosome cycle | |
Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProteasome subunit beta
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9NHX7
Organism-specific databases
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Component of the proteasome complex.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length282
- Mass (Da)31,162
- Last updated2000-10-01 v1
- ChecksumF4C0ED3DA320233F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF217726 EMBL· GenBank· DDBJ | AAF26416.1 EMBL· GenBank· DDBJ | Genomic DNA |