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Q9NHV9 · VAV_DROME

Function

function

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functionmetal ion binding
Biological Processactin cytoskeleton organization
Biological Processaxon guidance
Biological Processaxonogenesis
Biological Processborder follicle cell migration
Biological Processcell migration
Biological Processcentral nervous system development
Biological Processcompound eye morphogenesis
Biological Processdorsal closure
Biological Processepidermal growth factor receptor signaling pathway
Biological Processmelanotic encapsulation of foreign target
Biological Processmyoblast fusion
Biological Processnegative regulation of epidermal growth factor receptor signaling pathway
Biological Processopen tracheal system development
Biological Processphotoreceptor cell axon guidance
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of adherens junction organization
Biological Processvascular endothelial growth factor receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein vav
  • Short names
    DroVav; dVAV

Gene names

    • Name
      Vav
    • ORF names
      CG7893

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9NHV9
  • Secondary accessions
    • A2RVJ3
    • A4V4R6
    • Q8SWT3
    • Q8T061
    • Q9VWJ5

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000809831-793Protein vav

Post-translational modification

Phosphorylated on tyrosine residues.

Keywords

Proteomic databases

Expression

Tissue specificity

Ubiquitous.

Developmental stage

Expressed both maternally and zygotically in all stages of development.

Gene expression databases

Interaction

Subunit

Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, zinc finger.

Type
IDPosition(s)Description
Domain18-137Calponin-homology (CH)
Domain216-396DH
Domain432-541PH
Zinc finger552-601Phorbol-ester/DAG-type
Domain622-726SH2
Domain726-788SH3

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9NHV9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    793
  • Mass (Da)
    91,355
  • Last updated
    2002-07-11 v2
  • MD5 Checksum
    C2E310C44F7F1B0C293FF80AEDEB908A
MASSSSSNSFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQKLASEEL

Q9NHV9-2

  • Name
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-171: MASSSSSNSFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHST → MRRMRASRRPCFPTARAAMCASYPSISPWMWLAPRRMPHPMRSHPRRNRMPANRNHRWPPQRQAFLCPLHRGHLWAVWCPPPPHRRRFWSARASGCSERPPPSTTTAPRWRPPSTSMPTSTARTTRRSTRICATLPSRRRPNPS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M9PHJ6M9PHJ6_DROMEVav964
A8JUQ9A8JUQ9_DROMEVav1001

Sequence caution

The sequence AAM12266.1 differs from that shown. Reason: Miscellaneous discrepancy

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_0278011-171in isoform B
Sequence conflict53in Ref. 1; AAF28765
Sequence conflict148in Ref. 1; AAF28765
Sequence conflict372in Ref. 1; AAF28765
Sequence conflict503in Ref. 1; AAF28765
Sequence conflict645-664in Ref. 1; AAF28765
Sequence conflict739in Ref. 1; AAF28765

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF218780
EMBL· GenBank· DDBJ
AAF28765.1
EMBL· GenBank· DDBJ
mRNA
AE014298
EMBL· GenBank· DDBJ
AAF48943.3
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAN09485.1
EMBL· GenBank· DDBJ
Genomic DNA
AY069536
EMBL· GenBank· DDBJ
AAL39681.1
EMBL· GenBank· DDBJ
mRNA
AY095173
EMBL· GenBank· DDBJ
AAM12266.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
BT029984
EMBL· GenBank· DDBJ
ABM92858.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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