Q9NHP5 · TBP_DROVI
- ProteinTATA-box-binding protein
- GeneTbp
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids349 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | transcription factor TFIID complex | |
Molecular Function | DNA binding | |
Molecular Function | RNA polymerase III general transcription initiation factor activity | |
Biological Process | DNA-templated transcription initiation | |
Biological Process | transcription by RNA polymerase II | |
Biological Process | transcription by RNA polymerase III |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTATA-box-binding protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionQ9NHP5
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000153965 | 1-349 | TATA-box-binding protein | |||
Sequence: MDDIMSPNFSIPSIGHAPTPIHHSLDADQQIEALPHQVYHPAALDPTPTATTTVQQQQQPDGNNGVSAADGSGGSNLFGHEPSIPLAHKQSYQPSASYQQQQQQQQNQSSNTGGTTPQSLMQPQTPQSMMSHMMPMTSAAPPDASLSNIHQTMGPSTPMTPATPGSADPGIVPQLQNIVSTVNLCCKLDLKKIALHARNAEYNPKRFAPVIMRIREPRTTALIFSSGKMVCTGAKGEDDSRLAARKYARIIQKLGFRAKFLDLKIQNMVGLCDVKFPIRLEGLVLTHCNFSRYEPELFPGLIYRMVRPRIVLLLPAPGKVVLTGAKVRQEIYDAFDKIFSILKKFKKQS |
Interaction
Subunit
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MDDIMSPNFSIPSIGHAPTPIH | ||||||
Region | 42-142 | Disordered | ||||
Sequence: AALDPTPTATTTVQQQQQPDGNNGVSAADGSGGSNLFGHEPSIPLAHKQSYQPSASYQQQQQQQQNQSSNTGGTTPQSLMQPQTPQSMMSHMMPMTSAAPP | ||||||
Compositional bias | 46-71 | Polar residues | ||||
Sequence: PTPTATTTVQQQQQPDGNNGVSAADG | ||||||
Compositional bias | 88-134 | Polar residues | ||||
Sequence: HKQSYQPSASYQQQQQQQQNQSSNTGGTTPQSLMQPQTPQSMMSHMM | ||||||
Repeat | 175-251 | 1 | ||||
Sequence: LQNIVSTVNLCCKLDLKKIALHARNAEYNPKRFAPVIMRIREPRTTALIFSSGKMVCTGAKGEDDSRLAARKYARII | ||||||
Repeat | 265-342 | 2 | ||||
Sequence: IQNMVGLCDVKFPIRLEGLVLTHCNFSRYEPELFPGLIYRMVRPRIVLLLPAPGKVVLTGAKVRQEIYDAFDKIFSIL |
Sequence similarities
Belongs to the TBP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length349
- Mass (Da)38,258
- Last updated2000-10-01 v1
- Checksum3D2B5A13A56A753A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 46-71 | Polar residues | ||||
Sequence: PTPTATTTVQQQQQPDGNNGVSAADG | ||||||
Compositional bias | 88-134 | Polar residues | ||||
Sequence: HKQSYQPSASYQQQQQQQQNQSSNTGGTTPQSLMQPQTPQSMMSHMM |