Q9NHP5 · TBP_DROVI

Function

function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription factor TFIID complex
Molecular FunctionDNA binding
Molecular FunctionRNA polymerase III general transcription initiation factor activity
Biological ProcessDNA-templated transcription initiation
Biological Processtranscription by RNA polymerase II
Biological Processtranscription by RNA polymerase III

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    TATA-box-binding protein
  • Alternative names
    • TATA sequence-binding protein
    • TATA-binding factor
    • TATA-box factor
    • Transcription initiation factor TFIID TBP subunit

Gene names

    • Name
      Tbp

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    Q9NHP5

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001539651-349TATA-box-binding protein

Interaction

Subunit

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region1-22Disordered
Region42-142Disordered
Compositional bias46-71Polar residues
Compositional bias88-134Polar residues
Repeat175-2511
Repeat265-3422

Sequence similarities

Belongs to the TBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    349
  • Mass (Da)
    38,258
  • Last updated
    2000-10-01 v1
  • Checksum
    3D2B5A13A56A753A
MDDIMSPNFSIPSIGHAPTPIHHSLDADQQIEALPHQVYHPAALDPTPTATTTVQQQQQPDGNNGVSAADGSGGSNLFGHEPSIPLAHKQSYQPSASYQQQQQQQQNQSSNTGGTTPQSLMQPQTPQSMMSHMMPMTSAAPPDASLSNIHQTMGPSTPMTPATPGSADPGIVPQLQNIVSTVNLCCKLDLKKIALHARNAEYNPKRFAPVIMRIREPRTTALIFSSGKMVCTGAKGEDDSRLAARKYARIIQKLGFRAKFLDLKIQNMVGLCDVKFPIRLEGLVLTHCNFSRYEPELFPGLIYRMVRPRIVLLLPAPGKVVLTGAKVRQEIYDAFDKIFSILKKFKKQS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias46-71Polar residues
Compositional bias88-134Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF220262
EMBL· GenBank· DDBJ
AAF71711.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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