Q9NHA8 · BGBP3_DROME
- ProteinGram-negative bacteria-binding protein 3
- GeneGNBP3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids490 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Molecular Function | (1->3)-beta-D-glucan binding | |
Molecular Function | (1->3)-beta-D-glucan immune receptor activity | |
Molecular Function | lipopolysaccharide binding | |
Molecular Function | pattern recognition receptor activity | |
Biological Process | antifungal humoral response | |
Biological Process | antifungal innate immune response | |
Biological Process | carbohydrate metabolic process | |
Biological Process | detection of molecule of fungal origin | |
Biological Process | innate immune response-activating signaling pathway | |
Biological Process | pattern recognition receptor signaling pathway | |
Biological Process | positive regulation of melanization defense response | |
Biological Process | regulation of innate immune response | |
Biological Process | Toll receptor ligand protein activation cascade |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGram-negative bacteria-binding protein 3
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9NHA8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 16 | in strain: Netherlands line N22 | ||||
Sequence: L → Q | ||||||
Natural variant | 142 | in strain: Netherlands line N02 and Netherlands line N30 | ||||
Sequence: P → T | ||||||
Natural variant | 213 | in strain: Netherlands line N02, Netherlands line N07, Netherlands line N17 and Netherlands line N30 | ||||
Sequence: P → L | ||||||
Natural variant | 292 | in strain: Netherlands line N02 and Netherlands line N30 | ||||
Sequence: A → V | ||||||
Natural variant | 399 | in strain: Netherlands line N22 | ||||
Sequence: K → I | ||||||
Natural variant | 404 | in strain: Netherlands line N02 and Netherlands line N30 | ||||
Sequence: E → G | ||||||
Natural variant | 408 | in strain: Netherlands line N22 | ||||
Sequence: A → G | ||||||
Natural variant | 479 | in strain: Netherlands line N22 | ||||
Sequence: H → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MADALRFVAWSCCLQLLFLLLGVQG | ||||||
Chain | PRO_0000002819 | 26-490 | Gram-negative bacteria-binding protein 3 | |||
Sequence: YEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEGLEAGTWARDIVKAKNGRWTFRDRITALKPGDTLYYWTYVIYNGLGYREDDGSFVVNGYSGNNASPHPPVVPVSTTPWTPPADPDIDIRLGCTTPKTEVNGAPTRCAGQLVFVDEFNAAKLDPNKWKAERRFSGQPDYEFNVYVDDAPETLCLANGHVVLSTNTMKKQFKKGSGESLDLGEKCTGQANTHDCVRNGRTLNDGLPPMVTAQFSSKDFSFKYGRVEVRAKMPRAQWVTPQIWLQPRRPIYGVDDYRSGQLRIAYTRPNGGNLDLYGAAVLFADEPLRSVKNCLKPGTGNNSEDWSDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQAQKLEEGTGLAPFDQEFYLTFGLSVGGFNEYQHEIKPWNERAPQAQKAFWKEVKKIRDHWLDEGHMKIDYVKVYSL | ||||||
Glycosylation | 362 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 373 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed at very low levels during embryonic development. Expression increases during the larva stages and peaks at a moderate level during the late larval, prepupal and pupal stages, before decreasing in the adult.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-126 | CBM39 | ||||
Sequence: YEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEGLEAGTWARDIVKAKNGRWTFRDRITALKPGDTLYYWTYVIYNGLGYREDDGSFVVNGYSG | ||||||
Domain | 162-490 | GH16 | ||||
Sequence: TEVNGAPTRCAGQLVFVDEFNAAKLDPNKWKAERRFSGQPDYEFNVYVDDAPETLCLANGHVVLSTNTMKKQFKKGSGESLDLGEKCTGQANTHDCVRNGRTLNDGLPPMVTAQFSSKDFSFKYGRVEVRAKMPRAQWVTPQIWLQPRRPIYGVDDYRSGQLRIAYTRPNGGNLDLYGAAVLFADEPLRSVKNCLKPGTGNNSEDWSDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQAQKLEEGTGLAPFDQEFYLTFGLSVGGFNEYQHEIKPWNERAPQAQKAFWKEVKKIRDHWLDEGHMKIDYVKVYSL |
Sequence similarities
Belongs to the insect beta-1,3-glucan binding protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length490
- Mass (Da)55,211
- Last updated2007-07-10 v2
- ChecksumB442E16CC027D849
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 196 | in Ref. 1; AAF33851 | ||||
Sequence: R → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF228474 EMBL· GenBank· DDBJ | AAF33851.1 EMBL· GenBank· DDBJ | mRNA | ||
AM050231 EMBL· GenBank· DDBJ | CAJ18903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050232 EMBL· GenBank· DDBJ | CAJ18904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050233 EMBL· GenBank· DDBJ | CAJ18905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050234 EMBL· GenBank· DDBJ | CAJ18906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050235 EMBL· GenBank· DDBJ | CAJ18907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050236 EMBL· GenBank· DDBJ | CAJ18908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050237 EMBL· GenBank· DDBJ | CAJ18909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050238 EMBL· GenBank· DDBJ | CAJ18910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050239 EMBL· GenBank· DDBJ | CAJ18911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050240 EMBL· GenBank· DDBJ | CAJ18912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050241 EMBL· GenBank· DDBJ | CAJ18913.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM050242 EMBL· GenBank· DDBJ | CAJ18914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50349.1 EMBL· GenBank· DDBJ | Genomic DNA |