Q9NHA8 · BGBP3_DROME

Function

function

Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Function(1->3)-beta-D-glucan binding
Molecular Function(1->3)-beta-D-glucan immune receptor activity
Molecular Functionlipopolysaccharide binding
Molecular Functionpattern recognition receptor activity
Biological Processantifungal humoral response
Biological Processantifungal innate immune response
Biological Processcarbohydrate metabolic process
Biological Processdetection of molecule of fungal origin
Biological Processinnate immune response-activating signaling pathway
Biological Processpattern recognition receptor signaling pathway
Biological Processpositive regulation of melanization defense response
Biological Processregulation of innate immune response
Biological ProcessToll receptor ligand protein activation cascade

Keywords

Enzyme and pathway databases

Protein family/group databases

    • CBM39Carbohydrate-Binding Module Family 39
    • GH16Glycoside Hydrolase Family 16

Names & Taxonomy

Protein names

  • Recommended name
    Gram-negative bacteria-binding protein 3

Gene names

    • Name
      GNBP3
    • ORF names
      CG5008

Organism names

  • Taxonomic identifier
  • Strains
    • Netherlands line N01
    • Netherlands line N02
    • Netherlands line N03
    • Netherlands line N06
    • Netherlands line N07
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9NHA8
  • Secondary accessions
    • A0ZX55
    • A0ZX56
    • A0ZX59
    • A0ZX64
    • Q9VSR4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant16in strain: Netherlands line N22
Natural variant142in strain: Netherlands line N02 and Netherlands line N30
Natural variant213in strain: Netherlands line N02, Netherlands line N07, Netherlands line N17 and Netherlands line N30
Natural variant292in strain: Netherlands line N02 and Netherlands line N30
Natural variant399in strain: Netherlands line N22
Natural variant404in strain: Netherlands line N02 and Netherlands line N30
Natural variant408in strain: Netherlands line N22
Natural variant479in strain: Netherlands line N22

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_000000281926-490Gram-negative bacteria-binding protein 3
Glycosylation362N-linked (GlcNAc...) asparagine
Glycosylation373N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed at very low levels during embryonic development. Expression increases during the larva stages and peaks at a moderate level during the late larval, prepupal and pupal stages, before decreasing in the adult.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-126CBM39
Domain162-490GH16

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    490
  • Mass (Da)
    55,211
  • Last updated
    2007-07-10 v2
  • Checksum
    B442E16CC027D849
MADALRFVAWSCCLQLLFLLLGVQGYEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEGLEAGTWARDIVKAKNGRWTFRDRITALKPGDTLYYWTYVIYNGLGYREDDGSFVVNGYSGNNASPHPPVVPVSTTPWTPPADPDIDIRLGCTTPKTEVNGAPTRCAGQLVFVDEFNAAKLDPNKWKAERRFSGQPDYEFNVYVDDAPETLCLANGHVVLSTNTMKKQFKKGSGESLDLGEKCTGQANTHDCVRNGRTLNDGLPPMVTAQFSSKDFSFKYGRVEVRAKMPRAQWVTPQIWLQPRRPIYGVDDYRSGQLRIAYTRPNGGNLDLYGAAVLFADEPLRSVKNCLKPGTGNNSEDWSDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQAQKLEEGTGLAPFDQEFYLTFGLSVGGFNEYQHEIKPWNERAPQAQKAFWKEVKKIRDHWLDEGHMKIDYVKVYSL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict196in Ref. 1; AAF33851

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF228474
EMBL· GenBank· DDBJ
AAF33851.1
EMBL· GenBank· DDBJ
mRNA
AM050231
EMBL· GenBank· DDBJ
CAJ18903.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050232
EMBL· GenBank· DDBJ
CAJ18904.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050233
EMBL· GenBank· DDBJ
CAJ18905.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050234
EMBL· GenBank· DDBJ
CAJ18906.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050235
EMBL· GenBank· DDBJ
CAJ18907.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050236
EMBL· GenBank· DDBJ
CAJ18908.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050237
EMBL· GenBank· DDBJ
CAJ18909.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050238
EMBL· GenBank· DDBJ
CAJ18910.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050239
EMBL· GenBank· DDBJ
CAJ18911.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050240
EMBL· GenBank· DDBJ
CAJ18912.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050241
EMBL· GenBank· DDBJ
CAJ18913.1
EMBL· GenBank· DDBJ
Genomic DNA
AM050242
EMBL· GenBank· DDBJ
CAJ18914.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAF50349.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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