Q9NGD0 · ENPL_LEIIN

  • Protein
    Endoplasmin homolog
  • Gene
    LPG3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity).
Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate (By similarity).
Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain (By similarity).
Also required for addition of phosphoglycan to acid phosphatase (By similarity).
Not required for normal growth (By similarity).
Has ATPase activity (PubMed:29568220).
Binds heparin with micromolar affinity which may facilitate infection of host cells (PubMed:29568220).

Miscellaneous

Prominent antigen during human and canine visceral leishmaniasis.

Features

Showing features for binding site, site.

1771100200300400500600700
TypeIDPosition(s)Description
Binding site63ATP (UniProtKB | ChEBI)
Binding site109ATP (UniProtKB | ChEBI)
Binding site160ATP (UniProtKB | ChEBI)
Site405Important for ATP hydrolysis

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionheparin binding
Molecular Functionunfolded protein binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endoplasmin homolog
  • Alternative names
    • Glucose-regulated protein 94
    • Lipophosphoglycan biosynthetic protein 3

Gene names

    • Name
      LPG3
    • Synonyms
      GRP94

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MHOM/FR/78/LEM75
    • MCAN/IR/96/LON-49
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    Q9NGD0

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501014857025-771Endoplasmin homolog
Glycosylation63N-linked (GlcNAc...) asparagine
Glycosylation306N-linked (GlcNAc...) asparagine
Glycosylation402N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region253-282Disordered
Region727-771Disordered
Compositional bias740-771Acidic residues
Motif768-771Prevents secretion from ER

Sequence similarities

Belongs to the heat shock protein 90 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    771
  • Mass (Da)
    86,652
  • Last updated
    2000-10-01 v1
  • Checksum
    FAA3B8A1F3C08026
MANSSLLRVVLVALLLLGSVTVSAGDGRGTPIAFQAEVSKMLDILVNSLYTNRAVFLRELISNGSDALDKIRVLYLTSPKEPLTKDGEAPTMDLRISFDKEKSELILRDGGVGMTKEELAKHLGSLGTSGTKHFLEKLQEGVGAGGGDQNNLIGQFGVGFYSVFLVGDRVRVASKSDDSDEQYVWESKGDGQYFLYPDPRGNTLGRGTEITIELKPDAEQFLSAETIKKTIHQYSEFINFPIYVQEEVEVASTAATPEPAAEEGSLDEGAVEEDPDKEGDTQGVVKERRWTLVNENRPIWTRPIGNVTEEEYHTFYKAFSGDYRDPLYFNHFKVEGEVDFDSILFVPTTVDPASFSDDNSVPNTNIKLYVRRVFITDEFRDLLPRYLNFVKGIVDSNDLPLNVSREVLQESRILRVIKKKLVRKTLSMFADIAAQDEAIANGKQVESPAPSGHTHLKKPAYTKFWELYGKHLRLGVMLDSNNRNRLTKLFRYKSSRSESEYISLQTYVDRMKKGQKGIYYLSGDSVARIKKSPVLEDAVNHDVEVIFMTDAIDEYVVSQLTDFAGKKLINLAKEGVQLEESDARQRVADRKRKEKYDSFFTHLRALFGYSEVRKVILTKRMTNEAFLVSSGENQITARLASIMRGQSMSLANQQMTAERVLEVNYRHPLVDEMFKRFTVDEDDEVATDIAWVLYDTANLQAEFPVADVAAYSKRINRLLRSSVDLSADDSLLPPDDAEYTVSDTEAEEEEEQPKVDANADEEAEAVGEDDL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias740-771Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF253053
EMBL· GenBank· DDBJ
AAF67727.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ400675
EMBL· GenBank· DDBJ
ADP89477.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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