Q9NGD0 · ENPL_LEIIN
- ProteinEndoplasmin homolog
- GeneLPG3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids771 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity).
Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate (By similarity).
Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain (By similarity).
Also required for addition of phosphoglycan to acid phosphatase (By similarity).
Not required for normal growth (By similarity).
Has ATPase activity (PubMed:29568220).
Binds heparin with micromolar affinity which may facilitate infection of host cells (PubMed:29568220).
Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate (By similarity).
Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain (By similarity).
Also required for addition of phosphoglycan to acid phosphatase (By similarity).
Not required for normal growth (By similarity).
Has ATPase activity (PubMed:29568220).
Binds heparin with micromolar affinity which may facilitate infection of host cells (PubMed:29568220).
Miscellaneous
Prominent antigen during human and canine visceral leishmaniasis.
Features
Showing features for binding site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent protein folding chaperone | |
Molecular Function | heparin binding | |
Molecular Function | unfolded protein binding |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEndoplasmin homolog
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionQ9NGD0
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MANSSLLRVVLVALLLLGSVTVSA | ||||||
Chain | PRO_5010148570 | 25-771 | Endoplasmin homolog | |||
Sequence: GDGRGTPIAFQAEVSKMLDILVNSLYTNRAVFLRELISNGSDALDKIRVLYLTSPKEPLTKDGEAPTMDLRISFDKEKSELILRDGGVGMTKEELAKHLGSLGTSGTKHFLEKLQEGVGAGGGDQNNLIGQFGVGFYSVFLVGDRVRVASKSDDSDEQYVWESKGDGQYFLYPDPRGNTLGRGTEITIELKPDAEQFLSAETIKKTIHQYSEFINFPIYVQEEVEVASTAATPEPAAEEGSLDEGAVEEDPDKEGDTQGVVKERRWTLVNENRPIWTRPIGNVTEEEYHTFYKAFSGDYRDPLYFNHFKVEGEVDFDSILFVPTTVDPASFSDDNSVPNTNIKLYVRRVFITDEFRDLLPRYLNFVKGIVDSNDLPLNVSREVLQESRILRVIKKKLVRKTLSMFADIAAQDEAIANGKQVESPAPSGHTHLKKPAYTKFWELYGKHLRLGVMLDSNNRNRLTKLFRYKSSRSESEYISLQTYVDRMKKGQKGIYYLSGDSVARIKKSPVLEDAVNHDVEVIFMTDAIDEYVVSQLTDFAGKKLINLAKEGVQLEESDARQRVADRKRKEKYDSFFTHLRALFGYSEVRKVILTKRMTNEAFLVSSGENQITARLASIMRGQSMSLANQQMTAERVLEVNYRHPLVDEMFKRFTVDEDDEVATDIAWVLYDTANLQAEFPVADVAAYSKRINRLLRSSVDLSADDSLLPPDDAEYTVSDTEAEEEEEQPKVDANADEEAEAVGEDDL | ||||||
Glycosylation | 63 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 306 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 402 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 253-282 | Disordered | ||||
Sequence: TAATPEPAAEEGSLDEGAVEEDPDKEGDTQ | ||||||
Region | 727-771 | Disordered | ||||
Sequence: ADDSLLPPDDAEYTVSDTEAEEEEEQPKVDANADEEAEAVGEDDL | ||||||
Compositional bias | 740-771 | Acidic residues | ||||
Sequence: TVSDTEAEEEEEQPKVDANADEEAEAVGEDDL | ||||||
Motif | 768-771 | Prevents secretion from ER | ||||
Sequence: EDDL |
Sequence similarities
Belongs to the heat shock protein 90 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length771
- Mass (Da)86,652
- Last updated2000-10-01 v1
- ChecksumFAA3B8A1F3C08026
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 740-771 | Acidic residues | ||||
Sequence: TVSDTEAEEEEEQPKVDANADEEAEAVGEDDL |