Q9N623 · CRT_PLAFA
- ProteinChloroquine resistance transporter
- GeneCRT
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids424 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Variants
Filter Consequence
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Variant ID(s) | Position(s) | Change | Description | Clinical significance | Provenance | |
---|---|---|---|---|---|---|
72 | C>R | reduced sensitivity to quinine (UniProt) | UniProt | |||
72 | C>S | UniProt | ||||
74 | M>I | UniProt | ||||
75 | N>E | UniProt | ||||
75 | N>K | UniProt | ||||
76 | K>I | reduced sensitivity to quinine (UniProt) | UniProt | |||
76 | K>N | reduced sensitivity to quinine (UniProt) | UniProt | |||
76 | K>T | chloroquine resistance type 1; when associated with S-220 and in chloroquine resistance type 2; when associated with T-144; Y-160 and D-326; reduced sensitivity to drugs (UniProt) | UniProt | |||
97 | H>Q | UniProt | ||||
123 | H>R | UniProt | ||||
144 | A>T | chloroquine resistance type 2; when associated with T-76; Y-160 and D-326 (UniProt) | UniProt | |||
152 | T>A | UniProt | ||||
160 | L>Y | chloroquine resistance type 2; when associated with T-76; T-144 and D-326 (UniProt) | UniProt | |||
163 | S>R | may repel chloroquine from moving through the channel, leading to higher chloroquine accumulation at its site of action (UniProt) | UniProt | |||
205 | T>A | UniProt | ||||
220 | A>S | chloroquine resistance type 1; when associated with T-76 (UniProt) | UniProt | |||
271 | Q>E | UniProt | ||||
272 | L>F | causes the development of enlarged digestive vacuole in the asexual blood stages of the parasites, decreases peptide transport, increases sensitivity of parasites to chloroquine and quinine, decreases sensitivity to blasticidin, has no effect on sensitivity to mefloquine, amodiaquine, monodesethyl amodiaquine, piperaquine and artemisinin (UniProt) | UniProt | |||
275 | P>L | UniProt | ||||
326 | N>D | chloroquine resistance type 2; when associated with T-76; T-144 and Y-160 (UniProt) | UniProt | |||
326 | N>S | UniProt | ||||
333 | T>S | UniProt | ||||
334 | S>N | UniProt | ||||
352 | Q>K | reduced sensitivity to quinine (UniProt) | UniProt | |||
352 | Q>R | reduced sensitivity to quinine (UniProt) | UniProt | |||
356 | I>L | UniProt | ||||
356 | I>T | UniProt | ||||
356 | I>V | UniProt | ||||
371 | R>I | UniProt | ||||
371 | R>T | UniProt | ||||