Q9N623 · CRT_PLAFA

  • Protein
    Chloroquine resistance transporter
  • Gene
    CRT
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Variants

142450100150200250300350400100200300400

Filter Consequence

Filter Provenance

GAVLISTCMDNEQRKHFYWPd*GAVLISTCMDNEQRKHFYWPd*
Variant
ID(s)
Position(s)ChangeDescriptionClinical
significance
Provenance
72C>R
reduced sensitivity to quinine (UniProt)
UniProt
72C>S
UniProt
74M>I
UniProt
75N>E
UniProt
75N>K
UniProt
76K>I
reduced sensitivity to quinine (UniProt)
UniProt
76K>N
reduced sensitivity to quinine (UniProt)
UniProt
76K>T
chloroquine resistance type 1; when associated with S-220 and in chloroquine resistance type 2; when associated with T-144; Y-160 and D-326; reduced sensitivity to drugs (UniProt)
UniProt
97H>Q
UniProt
123H>R
UniProt
144A>T
chloroquine resistance type 2; when associated with T-76; Y-160 and D-326 (UniProt)
UniProt
152T>A
UniProt
160L>Y
chloroquine resistance type 2; when associated with T-76; T-144 and D-326 (UniProt)
UniProt
163S>R
may repel chloroquine from moving through the channel, leading to higher chloroquine accumulation at its site of action (UniProt)
UniProt
205T>A
UniProt
220A>S
chloroquine resistance type 1; when associated with T-76 (UniProt)
UniProt
271Q>E
UniProt
272L>F
causes the development of enlarged digestive vacuole in the asexual blood stages of the parasites, decreases peptide transport, increases sensitivity of parasites to chloroquine and quinine, decreases sensitivity to blasticidin, has no effect on sensitivity to mefloquine, amodiaquine, monodesethyl amodiaquine, piperaquine and artemisinin (UniProt)
UniProt
275P>L
UniProt
326N>D
chloroquine resistance type 2; when associated with T-76; T-144 and Y-160 (UniProt)
UniProt
326N>S
UniProt
333T>S
UniProt
334S>N
UniProt
352Q>K
reduced sensitivity to quinine (UniProt)
UniProt
352Q>R
reduced sensitivity to quinine (UniProt)
UniProt
356I>L
UniProt
356I>T
UniProt
356I>V
UniProt
371R>I
UniProt
371R>T
UniProt
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