Q9N290 · A4GAT_GORGO

Function

function

Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes.

Catalytic activity

Pathway

Glycolipid biosynthesis.

GO annotations

AspectTerm
Cellular ComponentGolgi membrane
Molecular Functionacetylglucosaminyltransferase activity
Molecular Functiongalactosyltransferase activity
Molecular Functionlactosylceramide 4-alpha-galactosyltransferase activity
Biological Processlipid metabolic process
Biological Processprotein O-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactosylceramide 4-alpha-galactosyltransferase
  • EC number
  • Alternative names
    • Alpha-1,4-N-acetylglucosaminyltransferase
    • Alpha-1,4-galactosyltransferase
    • Globotriaosylceramide synthase (Gb3 synthase)
    • UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

Gene names

    • Name
      A4GALT
    • Synonyms
      A14GALT, A4GALT1

Organism names

Accessions

  • Primary accession
    Q9N290

Proteomes

Subcellular Location

Golgi apparatus membrane
; Single-pass type II membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000805771-327Lactosylceramide 4-alpha-galactosyltransferase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif166-168DXD motif

Domain

The conserved DXD motif is involved in enzyme activity.

Sequence similarities

Belongs to the glycosyltransferase 32 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    327
  • Mass (Da)
    37,394
  • Last updated
    2000-10-01 v1
  • Checksum
    ED9A9A37A19F66B8
GFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIPCPTLAPPTPPSHGPAPGNIFFLETSDRTNPNFLFMCSVESAARTHPESHVLVLMKGLPGGNASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKNLRNLTNVLGTQSRYVLNGAFLAFERXHEFMALCMXDFVDHYNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDINPEELPRLFSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB041420
EMBL· GenBank· DDBJ
BAA94505.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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