Q9N181 · NMT2_BOVIN
- ProteinGlycylpeptide N-tetradecanoyltransferase 2
- GeneNMT2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids498 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.
Catalytic activity
- N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H+
- N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N6-tetradecanoyl)-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 117 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 122 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 250 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 252 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 258 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 260 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 261 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 262 | tetradecanoyl-CoA (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | glycylpeptide N-tetradecanoyltransferase activity | |
Molecular Function | peptidyl-lysine N6-myristoyltransferase activity | |
Biological Process | N-terminal peptidyl-glycine N-myristoylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycylpeptide N-tetradecanoyltransferase 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ9N181
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000064225 | 1-498 | Glycylpeptide N-tetradecanoyltransferase 2 | ||
Modified residue | 38 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | |||
Region | 1-87 | Disordered | |||
Compositional bias | 28-45 | Basic and acidic residues | |||
Compositional bias | 63-87 | Polar residues | |||
Sequence similarities
Belongs to the NMT family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length498
- Mass (Da)56,803
- Last updated2000-10-01 v1
- MD5 ChecksumD0E0D09A8B0CE23E217AF24AAAB2E397
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | |||
Compositional bias | 28-45 | Basic and acidic residues | |||
Compositional bias | 63-87 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF222687 EMBL· GenBank· DDBJ | AAF31456.1 EMBL· GenBank· DDBJ | mRNA |