Q9N181 · NMT2_BOVIN

  • Protein
    Glycylpeptide N-tetradecanoyltransferase 2
  • Gene
    NMT2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site117tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site122tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site250tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site252tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site258tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site260tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site261tetradecanoyl-CoA (UniProtKB | ChEBI)
Binding site262tetradecanoyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionglycylpeptide N-tetradecanoyltransferase activity
Molecular Functionpeptidyl-lysine N6-myristoyltransferase activity
Biological ProcessN-terminal peptidyl-glycine N-myristoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycylpeptide N-tetradecanoyltransferase 2
  • EC number
  • Alternative names
    • Myristoyl-CoA:protein N-myristoyltransferase 2 (NMT 2)
    • Peptide N-myristoyltransferase 2
    • Type II N-myristoyltransferase

Gene names

    • Name
      NMT2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q9N181

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000642251-498Glycylpeptide N-tetradecanoyltransferase 2
Modified residue38Phosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-18Polar residues
Region1-87Disordered
Compositional bias28-45Basic and acidic residues
Compositional bias63-87Polar residues

Sequence similarities

Belongs to the NMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    498
  • Mass (Da)
    56,803
  • Last updated
    2000-10-01 v1
  • MD5 Checksum
    D0E0D09A8B0CE23E217AF24AAAB2E397
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues
Compositional bias28-45Basic and acidic residues
Compositional bias63-87Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF222687
EMBL· GenBank· DDBJ
AAF31456.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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