Q9N0C5 · KITM_MACFA
- ProteinThymidine kinase 2, mitochondrial
- GeneTK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids265 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (By similarity).
In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (By similarity).
In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (By similarity).
Catalytic activity
- ATP + thymidine = ADP + dTMP + H+This reaction proceeds in the forward direction.
- 2'-deoxyuridine + ATP = ADP + dUMP + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | thymidine kinase activity | |
Biological Process | carbohydrate derivative metabolic process | |
Biological Process | DNA biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThymidine kinase 2, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionQ9N0C5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-33 | Mitochondrion | ||||
Sequence: MLLRPLRGWAALALRCFEPGSPGSPASGPGSRR | ||||||
Chain | PRO_0000016843 | 34-265 | Thymidine kinase 2, mitochondrial | |||
Sequence: VQRGAWPSDKEREKEKKSVICVEGNIASGKTTCLEFFSNATDIEVLTEPVSKWRNVRGHNPLGLMYQDASRWGLTLQTYVQLTMLDRHTCPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSIDLIVYLRTNPETCYQRLKRRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPVAAPVLVIEADHHMERMLQLFEQNRDRILTPENRKLGP |
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length265
- Mass (Da)30,744
- Last updated2000-10-01 v1
- Checksum6104E608C0E809A0
Keywords
- Technical term