Q9MDK5 · Q9MDK5_DROME

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      mt:ND4
    • Synonyms
      nad4
      , NADH4
      , ND4
    • ORF names
      CG34085

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Oregon R
    • Zimbabwe 53
    • Paris
    • Alstonvl
    • Brownsvl
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9MDK5

Organism-specific databases

Subcellular Location

Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-36Helical
Transmembrane56-75Helical
Transmembrane87-104Helical
Transmembrane110-132Helical
Transmembrane139-162Helical
Transmembrane182-204Helical
Transmembrane216-235Helical
Transmembrane247-265Helical
Transmembrane272-295Helical
Transmembrane301-323Helical
Transmembrane335-356Helical
Transmembrane376-399Helical

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-103NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain106-391NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    51,357
  • Last updated
    2000-10-01 v1
  • Checksum
    B70C0AA45225C96D
MLKIIFFLLFLIPFCFINNMYWMVQIMMFFISFIFLLMNNFMNYWSEISYFLGCDMLSYGLILLSLWICSLMLLASEMINKHNNYKNLFLLNIIILLLLLILTFSSMSLFMFYLFFESSLIPTLFLILGWGYQPERLQAGLYLLFYTLLVSLPMLIGIFYVMNKIGSMNFYLMNNFMFNYDLLYFCLLCAFLVKMPMFLVHLWLPKAHVEAPVSGSMILAGIMLKLGGYGMLRVISFLQLMNLKYSFVWISISLVGGVLVSLVCLRQTDLKALIAYSSVAHMGIVLSGLLTMTYWGLCGSYTLMIAHGLCSSGLFCLANVSYERLGSRSMLINKGLLNFMPSMTLWWFLLSSANMAAPPTLNLLGEISLLNSIVSWSWISMILLSFLSFFSAAYTLYLYSFSQHGKLFSGVYSFSSGKIREYLLMLLHWLPLNLLILKSESFMLWL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF200828
EMBL· GenBank· DDBJ
AAF77234.1
EMBL· GenBank· DDBJ
Genomic DNA
AF200829
EMBL· GenBank· DDBJ
AAF77246.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ190105
EMBL· GenBank· DDBJ
ACI28550.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ190106
EMBL· GenBank· DDBJ
ACI28563.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ190107
EMBL· GenBank· DDBJ
ACI28576.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ190109
EMBL· GenBank· DDBJ
ACI28602.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ229525
EMBL· GenBank· DDBJ
ACT21552.1
EMBL· GenBank· DDBJ
mRNA
JN418337
EMBL· GenBank· DDBJ
AFK30477.1
EMBL· GenBank· DDBJ
Genomic DNA
JN418360
EMBL· GenBank· DDBJ
AFK30520.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686693
EMBL· GenBank· DDBJ
AFP47054.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686694
EMBL· GenBank· DDBJ
AFP47067.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686695
EMBL· GenBank· DDBJ
AFP47080.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686696
EMBL· GenBank· DDBJ
AFP47093.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686697
EMBL· GenBank· DDBJ
AFP47106.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ686698
EMBL· GenBank· DDBJ
AFP47119.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266575
EMBL· GenBank· DDBJ
AFR59652.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266576
EMBL· GenBank· DDBJ
AFR59665.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266577
EMBL· GenBank· DDBJ
AFR59678.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266579
EMBL· GenBank· DDBJ
AFR59704.1
EMBL· GenBank· DDBJ
Genomic DNA
KM244693
EMBL· GenBank· DDBJ
AIW06285.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843842
EMBL· GenBank· DDBJ
AKN22191.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843843
EMBL· GenBank· DDBJ
AKN22208.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843844
EMBL· GenBank· DDBJ
AKN22221.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843846
EMBL· GenBank· DDBJ
AKN22247.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843847
EMBL· GenBank· DDBJ
AKN22260.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843848
EMBL· GenBank· DDBJ
AKN22273.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843851
EMBL· GenBank· DDBJ
AKN22312.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843852
EMBL· GenBank· DDBJ
AKN22325.1
EMBL· GenBank· DDBJ
Genomic DNA
KP843854
EMBL· GenBank· DDBJ
AKN22351.1
EMBL· GenBank· DDBJ
Genomic DNA
KT174472
EMBL· GenBank· DDBJ
ALC75248.1
EMBL· GenBank· DDBJ
Genomic DNA
KT174473
EMBL· GenBank· DDBJ
ALC75261.1
EMBL· GenBank· DDBJ
Genomic DNA
KT174474
EMBL· GenBank· DDBJ
ALC75274.1
EMBL· GenBank· DDBJ
Genomic DNA
KU764535
EMBL· GenBank· DDBJ
ANC75328.1
EMBL· GenBank· DDBJ
Genomic DNA
KX889415
EMBL· GenBank· DDBJ
APO15277.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559383
EMBL· GenBank· DDBJ
AQT26260.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559384
EMBL· GenBank· DDBJ
AQT26273.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559385
EMBL· GenBank· DDBJ
AQT26286.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559386
EMBL· GenBank· DDBJ
AQT26299.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559387
EMBL· GenBank· DDBJ
AQT26312.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559389
EMBL· GenBank· DDBJ
AQT26338.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559390
EMBL· GenBank· DDBJ
AQT26351.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559391
EMBL· GenBank· DDBJ
AQT26364.1
EMBL· GenBank· DDBJ
Genomic DNA
KY559392
EMBL· GenBank· DDBJ
AQT26377.1
EMBL· GenBank· DDBJ
Genomic DNA
KY310614
EMBL· GenBank· DDBJ
ARN59093.1
EMBL· GenBank· DDBJ
Genomic DNA
KY310615
EMBL· GenBank· DDBJ
ARN59106.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ400907
EMBL· GenBank· DDBJ
CAB91059.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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