Q9MD82 · Q9MD82_MOUSE
- ProteinNADH-ubiquinone oxidoreductase chain 5
- Genemt-Nd5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone | |
Biological Process | mitochondrial respiratory chain complex I assembly | |
Biological Process | response to hydrogen peroxide | |
Biological Process | response to hypoxia | |
Biological Process | response to organonitrogen compound |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9MD82
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-27 | Helical | ||||
Sequence: TSILLIFILLLSPILISMSNLI | ||||||
Transmembrane | 39-56 | Helical | ||||
Sequence: SIKFSFIISLLPLLMFFH | ||||||
Transmembrane | 84-105 | Helical | ||||
Sequence: FFSILFTSVALFVTWSIMQFSS | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FIKYLTLFLITMLILTSA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLIGWWYG | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: ILYNRIGDIGFILAMVWFSL | ||||||
Transmembrane | 211-233 | Helical | ||||
Sequence: IPLMGLLIAATGKSAQFGLHPWL | ||||||
Transmembrane | 245-266 | Helical | ||||
Sequence: ALLHSSTMVVAGIFLLVRFHPL | ||||||
Transmembrane | 272-294 | Helical | ||||
Sequence: FILTTMLCLGALTTLFTAICALT | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: IIAFSTSSQLGLMMVTLGM | ||||||
Transmembrane | 325-347 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFMCSGSII | ||||||
Transmembrane | 368-386 | Helical | ||||
Sequence: FTSSCLVIGSLALTGMPFL | ||||||
Transmembrane | 406-432 | Helical | ||||
Sequence: AWALLITLIATSMTAMYSMRIIYFVTM | ||||||
Transmembrane | 453-472 | Helical | ||||
Sequence: PIKRLAFGSIFAGFVISYNI | ||||||
Transmembrane | 484-504 | Helical | ||||
Sequence: WFLKTTALIISVLGFLIALEL | ||||||
Transmembrane | 586-604 | Helical | ||||
Sequence: LYFMSFLINIILIIILYSI |
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-117 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQFSSWYMHSDPNINRF | ||||||
Domain | 134-417 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNMFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHPLTTNNNFILTTMLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAFFKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALLITLIATS | ||||||
Domain | 422-601 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSMRIIYFVTMTKPRFPPLISINENDPDLMNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLTMKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKSTSTLHTNMTTLTTNQKGLIKLYFMSFLINIILIIIL |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)68,475
- Last updated2000-10-01 v1
- Checksum31C10862CDC78B10
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY466499 EMBL· GenBank· DDBJ | AAR21205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533105 EMBL· GenBank· DDBJ | AAS01436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533106 EMBL· GenBank· DDBJ | AAS01449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533107 EMBL· GenBank· DDBJ | AAS01462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY533108 EMBL· GenBank· DDBJ | AAS01475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY999076 EMBL· GenBank· DDBJ | AAX83022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108330 EMBL· GenBank· DDBJ | ABK79103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108331 EMBL· GenBank· DDBJ | ABK79116.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108332 EMBL· GenBank· DDBJ | ABK79129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108333 EMBL· GenBank· DDBJ | ABK79142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108334 EMBL· GenBank· DDBJ | ABK79155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108335 EMBL· GenBank· DDBJ | ABK79168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108336 EMBL· GenBank· DDBJ | ABK79181.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108337 EMBL· GenBank· DDBJ | ABK79194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108338 EMBL· GenBank· DDBJ | ABK79207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108339 EMBL· GenBank· DDBJ | ABK79220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108340 EMBL· GenBank· DDBJ | ABK79233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF108341 EMBL· GenBank· DDBJ | ABK79246.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312160 EMBL· GenBank· DDBJ | ABX79712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU312161 EMBL· GenBank· DDBJ | ABX79725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315228 EMBL· GenBank· DDBJ | ABX79738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU315229 EMBL· GenBank· DDBJ | ABX79751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU450583 EMBL· GenBank· DDBJ | ACA01533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ803909 EMBL· GenBank· DDBJ | ACN91105.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ586004 EMBL· GenBank· DDBJ | ADR03166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ877407 EMBL· GenBank· DDBJ | ADW83076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF286601 EMBL· GenBank· DDBJ | ADZ23173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675026 EMBL· GenBank· DDBJ | AEN03379.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675027 EMBL· GenBank· DDBJ | AEN03392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675028 EMBL· GenBank· DDBJ | AEN03405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675029 EMBL· GenBank· DDBJ | AEN03418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675030 EMBL· GenBank· DDBJ | AEN03431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ675031 EMBL· GenBank· DDBJ | AEN03444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ003190 EMBL· GenBank· DDBJ | AEV56607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP090294 EMBL· GenBank· DDBJ | AJE26566.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260514 EMBL· GenBank· DDBJ | AJK91496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260515 EMBL· GenBank· DDBJ | AJK91509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260516 EMBL· GenBank· DDBJ | AJK91522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP260517 EMBL· GenBank· DDBJ | AJK91535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR020497 EMBL· GenBank· DDBJ | AKS10722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY018919 EMBL· GenBank· DDBJ | ART65703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042524 EMBL· GenBank· DDBJ | BAA95650.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042523 EMBL· GenBank· DDBJ | BAA95663.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB042809 EMBL· GenBank· DDBJ | BAA95805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB049357 EMBL· GenBank· DDBJ | BAB13811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK140457 EMBL· GenBank· DDBJ | BAE24397.1 EMBL· GenBank· DDBJ | mRNA | ||
AP013030 EMBL· GenBank· DDBJ | BAM93593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014540 EMBL· GenBank· DDBJ | BAO42860.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014541 EMBL· GenBank· DDBJ | BAO42873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ489607 EMBL· GenBank· DDBJ | CAD33917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ512208 EMBL· GenBank· DDBJ | CAD54442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT937073 EMBL· GenBank· DDBJ | QPG85865.1 EMBL· GenBank· DDBJ | Genomic DNA |