Q9M9S3 · WHY1_ARATH

Function

function

Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology-dependent illegitimate recombinations. In nucleus, modulates telomere length homeostasis by inhibiting the action of the telomerase at the extreme termini of chromosomes. Is recruited to a distal element upstream of the kinesin KP1 to mediate the transcriptional repression of KP1. Is required for full salicylic acid-dependent plant disease resistance responses. Can bind double-stranded DNA in vivo.

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast
Cellular Componentchloroplast nucleoid
Cellular Componentchromosome, telomeric region
Cellular ComponentDNA repair complex
Cellular Componentextracellular region
Molecular FunctionDNA binding
Molecular FunctionmRNA binding
Molecular Functionsingle-stranded DNA binding
Molecular Functiontelomeric DNA binding
Biological Processdefense response
Biological ProcessDNA repair
Biological Processnegative regulation of telomere maintenance via telomerase
Biological Processregulation of DNA-templated transcription
Biological Processregulation of telomere maintenance
Biological Processsalicylic acid mediated signaling pathway
Biological Processsystemic acquired resistance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Single-stranded DNA-binding protein WHY1, chloroplastic
  • Alternative names
    • Protein PLASTID TRANSCRIPTIONALLY ACTIVE 1
    • Protein WHIRLY 1 (AtWHY1)

Gene names

    • Name
      WHY1
    • Synonyms
      PTAC1
    • ORF names
      F14L17.18
    • Ordered locus names
      At1g14410

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9M9S3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but mutant plants present a progressive lengthening of telomeric repeats.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis91No effect on DNA binding. Affects its function in DNA repair.
Mutagenesis148In atwhy1.2; reduces binding activity to single-stranded DNA.
Mutagenesis183In atwhy1.1; reduces binding activity to single-stranded DNA.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-47Chloroplast
ChainPRO_000042044748-263Single-stranded DNA-binding protein WHY1, chloroplastic

Proteomic databases

Expression

Induction

By salicylic acid (SA) and infection by H.parasitica.

Gene expression databases

Interaction

Subunit

Homotetramer.

Complex viewer

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region89-94Required for ssDNA binding
Motif167-180Nuclear localization signal

Sequence similarities

Belongs to the Whirly family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    263
  • Mass (Da)
    29,058
  • Last updated
    2000-10-01 v1
  • Checksum
    E90F85763198C614
MSQLLSTPLMAVNSNPRFLSSSSVLVTGGFAVKRHGFALKPTTKTVKLFSVKSRQTDYFEKQRFGDSSSSPSPAEGLPARFYVGHSIYKGKAALTVDPRAPEFVALDSGAFKLSKDGFLLLQFAPSAGVRQYDWSKKQVFSLSVTEIGTLVSLGPRESCEFFHDPFKGKSDEGKVRKVLKVEPLPDGSGHFFNLSVQNKLVNVDESIYIPITRAEFAVLISAFNFVLPYLIGWHAFANSIKPEETSRVNNASPNYGGDYEWNR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC012188
EMBL· GenBank· DDBJ
AAF43941.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE29160.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332452
EMBL· GenBank· DDBJ
AAG48815.1
EMBL· GenBank· DDBJ
mRNA
AF370156
EMBL· GenBank· DDBJ
AAK43971.1
EMBL· GenBank· DDBJ
mRNA
AY059097
EMBL· GenBank· DDBJ
AAL15203.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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