Q9M8Z7 · U80A2_ARATH
- ProteinSterol 3-beta-glucosyltransferase UGT80A2
- GeneUGT80A2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids637 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the biosynthesis of sterol glucosides. Catalyzes the synthesis of steryl glycosides (SGs) and acyl steryl glycosides (ASGs) which are the most abundant sterol derivatives in higher plants. Can act on several sterols like sitosterol, campesterol and stigmasterol. Both UGT80A2 and UGT80B1 are required for the normal production of SGs and ASGs in seeds.
Catalytic activity
- a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H+
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | sterol 3-beta-glucosyltransferase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | lipid glycosylation | |
Biological Process | seed development | |
Biological Process | sterol biosynthetic process | |
Biological Process | sterol metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSterol 3-beta-glucosyltransferase UGT80A2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9M8Z7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Reduced growth rates.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000422074 | 1-637 | Sterol 3-beta-glucosyltransferase UGT80A2 | |||
Sequence: MPEISPAELAKVSSSSSSSSSSSSGRASVKIEEIEGGAAASGVVIVSEELETNPKTVVASIADETVAESSGTGNKSFSRVWTMPLEGSSSSDKAESSSTNQPRLDKSKTERQQKVTHILAEDAAKIFDDKISAGKKLKLLNRIATVKHDGTVEFEVPADAIPQPIVVDRGESKNGVCADESIDGVDLQYIPPMQIVMLIVGTRGDVQPFVAIAKRLQDYGHRVRLATHANFKEFVLTAGLEFYPLGGDPKVLAGYMVKNKGFLPSGPSEIPIQRNQMKDIIYSLLPACKEPDPDSGISFKADAIIANPPAYGHTHVAEALKIPIHVFFTMPWTPTSEFPHPLSRVKQPAGYRLSYQIVDSLIWLGIRDMVNDLRKKKLKLRPVTYLSGTQGSGSNIPHGYMWSPHLVPKPKDWGPQIDVVGFCYLDLASNYEPPAELVEWLEAGDKPIYIGFGSLPVQEPEKMTEIIVEALQRTKQRGIINKGWGGLGNLKEPKDFVYLLDNVPHDWLFPRCKAVVHHGGAGTTAAGLKASCPTTIVPFFGDQPFWGERVHARGVGPSPIPVDEFSLHKLEDAINFMLDDKVKSSAETLAKAMKDEDGVAGAVKAFFKHLPSAKQNISDPIPEPSGFLSFRKCFGCS |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, cauline leaf epidermal cells, stomata, stamen, pollen and around the base of siliques.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-29 | Disordered | ||||
Sequence: MPEISPAELAKVSSSSSSSSSSSSGRASV | ||||||
Compositional bias | 9-28 | Polar residues | ||||
Sequence: LAKVSSSSSSSSSSSSGRAS | ||||||
Compositional bias | 66-103 | Polar residues | ||||
Sequence: VAESSGTGNKSFSRVWTMPLEGSSSSDKAESSSTNQPR | ||||||
Region | 66-112 | Disordered | ||||
Sequence: VAESSGTGNKSFSRVWTMPLEGSSSSDKAESSSTNQPRLDKSKTERQ |
Sequence similarities
Belongs to the glycosyltransferase 28 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9M8Z7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length637
- Mass (Da)69,277
- Last updated2000-10-01 v1
- Checksum11FF5572F5FA4094
Q9M8Z7-2
- Name2
- Differences from canonical
- 636-636: C → F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I9LNA9 | A0A1I9LNA9_ARATH | SGT | 555 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 9-28 | Polar residues | ||||
Sequence: LAKVSSSSSSSSSSSSGRAS | ||||||
Compositional bias | 66-103 | Polar residues | ||||
Sequence: VAESSGTGNKSFSRVWTMPLEGSSSSDKAESSSTNQPR | ||||||
Sequence conflict | 93 | in Ref. 1; CAB06082 | ||||
Sequence: K → R | ||||||
Alternative sequence | VSP_046337 | 636 | in isoform 2 | |||
Sequence: C → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z83833 EMBL· GenBank· DDBJ | CAB06082.1 EMBL· GenBank· DDBJ | mRNA | ||
AC016827 EMBL· GenBank· DDBJ | AAF27006.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE74489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE74490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY057496 EMBL· GenBank· DDBJ | AAL09737.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AY079032 EMBL· GenBank· DDBJ | AAL79582.1 EMBL· GenBank· DDBJ | mRNA | ||
AK316817 EMBL· GenBank· DDBJ | BAH19530.1 EMBL· GenBank· DDBJ | mRNA |