Q9M8S0 · MBS1_ARATH

Function

function

Required for acclimation to reactive oxygen species (ROS) responses downstream of beta-cyclocitral (beta-cc) or mediated by dihydroactinidiolide, including singlet oxygen 1O2 detoxification reactions, especially upon light-mediated photooxidative stress, and leading to programmed cell death (PubMed:24151292, PubMed:27813110).
Prevents leaf senescence (PubMed:24151292).
Involved in cold acclimation (PubMed:27813110).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic stress granule
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processcellular response to singlet oxygen
Biological Processcold acclimation
Biological Processregulation of DNA-templated transcription
Biological Processregulation of leaf senescence
Biological Processresponse to high light intensity
Biological Processresponse to photooxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein METHYLENE BLUE SENSITIVITY 1

Gene names

    • Name
      MBS1
    • ORF names
      F13E7.27
    • Ordered locus names
      At3g02790

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9M8S0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Cytoplasm
Note: Moves from homogeneous distribution in the cytosol to discrete spots (e.g. stress granules (SGs) and processing bodies (PBs)) in response to singlet oxygen 1O2 exposure (PubMed:24151292).
Accumulates in nucleus after beta-cyclocitral (beta-cc) treatment (PubMed:27813110).

Keywords

Phenotypes & Variants

Disruption phenotype

Normal plants under standard growth conditions, but severe symptoms of photooxidative damage under excess light due to a deficient induction of singlet oxygen 1O2 detoxification reactions, thus leading to pale leaf phenotype, early senescence and lack of anthocyanin accumulation (PubMed:24151292, PubMed:27813110).
Increased susceptibility to low temperatures and high photon flux density (PFD) conditions. Increased lipid peroxidation in response to beta-cyclocitral (beta-cc) associated with reduced induction of reactive oxygen species (ROS) responsive genes (e.g. AAA, LTI30, ZAT12 and WRKY40). Altered induction of gene (e.g. AAA, OXI1, CAT2, APX1 and RD20) expression in response to the lactone dihydroactinidiolide (PubMed:27813110).
Accumulation of singlet oxygen 1O2 in chloroplasts in response to light stress. Early senescence of the older leaves. Plants lacking both MBS1 and MBS2 exhibit premature leaf senescence (PubMed:24151292).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 9 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004449001-105Protein METHYLENE BLUE SENSITIVITY 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Mainly expressed in the epidermis.

Induction

By high light (PubMed:24151292).
Triggered by the carotenoid metabolite beta-cyclocitral (beta-cc) (PubMed:27813110).

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region26-46Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    105
  • Mass (Da)
    11,278
  • Last updated
    2000-10-01 v1
  • Checksum
    4F882E77711B5514
MTGKAKPKKHTAKEIQAKIDAALTNRGGGKAGIADRTGKEKGGHAKYECPHCKITAPGLKTMQIHHESKHPNIIYEESKLVNLHAVLAPVAESKPKPGIRGSLKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC018363
EMBL· GenBank· DDBJ
AAF26981.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE73860.1
EMBL· GenBank· DDBJ
Genomic DNA
AF361599
EMBL· GenBank· DDBJ
AAK32767.1
EMBL· GenBank· DDBJ
mRNA
AY058229
EMBL· GenBank· DDBJ
AAL15403.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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