Q9M8D3 · PUR4_ARATH

Function

function

Essential to the male gametophyte development. Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

114071002003004005006007008009001,0001,1001,2001,3001,400
TypeIDPosition(s)Description
Binding site407-418ATP (UniProtKB | ChEBI)
Binding site487-489ATP (UniProtKB | ChEBI)
Binding site786ATP (UniProtKB | ChEBI)
Binding site787Mg2+ (UniProtKB | ChEBI)
Binding site826Mg2+ (UniProtKB | ChEBI)
Binding site830Mg2+ (UniProtKB | ChEBI)
Binding site989Mg2+ (UniProtKB | ChEBI)
Binding site991ATP (UniProtKB | ChEBI)
Active site1235Nucleophile
Active site1366
Active site1368

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentchloroplast stroma
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processmicrogametogenesis
Biological Processpollen development

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial
  • EC number
  • Short names
    FGAM synthase; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase (FGAR amidotransferase; FGAR-AT)
    • Formylglycinamide ribotide amidotransferase

Gene names

    • ORF names
      F1O17.7
    • Ordered locus names
      At1g74260

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9M8D3
  • Secondary accessions
    • A9Y5J1
    • F4HTW2

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Lethal to the male gametophyte.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 78 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-53Chloroplast and mitochondrion
ChainPRO_000002988054-1407Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1141-1381Glutamine amidotransferase type-1

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,407
  • Mass (Da)
    153,954
  • Last updated
    2012-06-13 v3
  • Checksum
    49F270F0E2CEBDCB
MNTSQATRAALFLNGSNRQAMLLQRSSMSQLWGSVRMRTSRLSLNRTKAVSLRCSAQPNKPKAAVSTGSFVTADELPSLVEKPAAEVIHFYRVPLIQESANAELLKAVQTKISNQIVSLTTEQSFNIGLESKLKDEKLSVLKWILQETYEPENLGTDSFLERKKQEGLHAVIVEVGPRLSFTTAWSTNAVSICRACGLDEVTRLERSRRYLLFSKEPLLENQIKEFAAMVHDRMTECVYTQKLVSFETNVVPEEVKYVPVMEKGRKALEEINQEMGLAFDEQDLQYYTRLFREDIKRDPTNVELFDIAQSNSEHSRHWFFAGNMVIDGKPMDKSLMQIVKSTWEANRNNSVIGFKDNSSAIRGFLVNQLRPLLPGSVCLLDVSARDLDILFTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGSFVVASTSGYCVGNLNMEGSYAPWEDSSFQYPSNLASPLQILIDASNGASDYGNKFGEPMIQGYTRTFGMRLPSGDRREWLKPIMFSAGIGQIDHTHITKGEPEVGMLVVKIGGPAYRIGMGGGAASSMVSGQNDAELDFNAVQRGDAEMSQKLYRVVRACIEMGEKNPIISIHDQGAGGNCNVVKEIIYPQGAEIDIRAVVVGDHTMSVLEIWGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCTLIDSTAAAKCSKEGLPPPPPAVDLELEKVLGDMPKKTFKFNRIAYAREPLDIAPGITLMDALKRVLRLPSVSSKRFLTTKVDRCVTGLVAQQQTVGPLQITLADVAVIAQTFTDLTGGACAIGEQPIKGLLDPKAMARLAVGEALTNLVWAKVTALSDVKASGNWMYAAKLEGEGSAMYDAAIALSEAMIELGIAIDGGKDSLSMAAHADGEVVKAPGNLVISAYVTCPDITKTVTPDLKLGGDDGILLHVDLAKGKRRLGGSALAQVFGQIGNDCPDLDDVPYLKNVFDGVQALIAENLVSAGHDISDGGLVVTALEMAFAGNKGINLDLASNGISLFETLFSEELGLVLEISKTNLDAVMEKLRAFDVTAEIIGNVTDSPLIEVKVDGITHLSEKTSFLRDMWEDTSFQLEKLQRLASCVEMEKEGLKFRHEPNWKLSFIPSSTNNNYMSQDVKPKVAVIREEGSNGDREMSAAFYAAGFEPWDVTVSDLLAGDITLDQFRGIVFVGGFSYADVLDSAKGWAASIRFNEPVLSQFQEFYKRPDTFSLGICNGCQLMALLGWVPGPQVGGSLDTSQPRFVHNESGRFECRFTSVTIKDSPSIMLKGMEGSTLGVWAAHGEGRAYFPDEGVLDHMLHSDLAPLRYCDDDGNVTEAYPFNLNGSPLGIAAICSPDGRHLAMMPHPERCFLMWQFPWYPTSWDVEKAGPSPWLKMFQNARDWLESC

Sequence caution

The sequence AAG52403.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence ABW87767.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU091297
EMBL· GenBank· DDBJ
ABW87767.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC020579
EMBL· GenBank· DDBJ
AAG52403.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE35571.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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