Q9M811 · ROGFB_ARATH
- ProteinRop guanine nucleotide exchange factor 11
- GeneROPGEF11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids543 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Functions as a light-signaling switch that functions in root growth and development through the activation of Rop in a phytochrome-dependent manner. May act as a negative regulator of phytochrome-mediated primary root development.
Miscellaneous
Plants overexpressing ROPGEF11 show retarded root elongation and irregular root hair formation.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Biological Process | root development | |
Biological Process | root hair cell development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameRop guanine nucleotide exchange factor 11
- Short namesAtRopGEF11
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9M811
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Interacts with PHYA and PHYB in the cytoplasm in darkness.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000423896 | 1-543 | Rop guanine nucleotide exchange factor 11 | ||
Proteomic databases
Expression
Tissue specificity
Highly expressed in elongating regions of roots and pollen grains. Expressed in flowers, and at lower levels in leaves and stems.
Gene expression databases
Interaction
Subunit
Interacts with ARAC4/ROP2, ARAC3/ROP, ARAC9/ROP8, PHYA and PHYB.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9M811 | ROPGEF1 Q93ZY2 | 3 | EBI-16206717, EBI-4425188 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 61-89 | Disordered | |||
Domain | 95-456 | PRONE | |||
Domain
The PRONE (plant-specific Rop nucleotide exchanger) domain is responsible for the GEF activity.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q9M811-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length543
- Mass (Da)61,655
- Last updated2016-02-17 v2
- Checksum0E0DF925F43F4B42
Sequence caution
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC022354 EMBL· GenBank· DDBJ | AAF29411.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
CP002684 EMBL· GenBank· DDBJ | AEE32773.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT033039 EMBL· GenBank· DDBJ | ACE79741.1 EMBL· GenBank· DDBJ | mRNA |