Q9M199 · IQD13_ARATH

Function

function

May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Regulates the formation of oval xylem secondary cell-wall deposition pits through microtubule-dependent lateral inhibition of Rho GTPase domains, thus confining the area of active ROP domains within the lattice of the cortical microtubules (PubMed:28803875).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcortical microtubule
Cellular Componentplasma membrane
Molecular Functioncalmodulin binding
Biological Processplant-type secondary cell wall biogenesis
Biological Processregulation of secondary cell wall biogenesis
Biological Processresponse to calcium ion
Biological Processxylem development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein IQ-DOMAIN 13
  • Short names
    AtIQD13

Gene names

    • Name
      IQD13
    • ORF names
      T16L24.240
    • Ordered locus names
      At3g59690

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9M199

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
Note: Recruits calmodulin (CaM2) to microtubules (PubMed:28115582).
Associates with cortical microtubules and the plasma membrane to laterally restrict the localization of ROP GTPase domains (PubMed:28803875).

Keywords

Phenotypes & Variants

Disruption phenotype

Formation of abnormally large and round secondary cell-wall pits in roots metaxylem vessels (PubMed:28803875).
The double mutant iqd13 iqd14 exhibits larger secondary cell-wall pits (PubMed:28803875).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 44 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004531201-517Protein IQ-DOMAIN 13

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in vessels of roots, cotyledons and leaves, as well as in trichomes.

Developmental stage

In roots, mostly localized to microtubule-like filaments beneath the secondary cell walls of metaxylem cells.

Gene expression databases

Interaction

Subunit

Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-11Calmodulin-binding
Region1-60Disordered
Compositional bias32-49Basic and acidic residues
Region81-147Disordered
Compositional bias86-102Polar residues
Compositional bias130-146Pro residues
Domain168-196IQ 1
Domain197-218IQ 2
Compositional bias324-390Polar residues
Region324-407Disordered
Region425-452Disordered
Compositional bias428-444Basic and acidic residues

Sequence similarities

Belongs to the IQD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    517
  • Mass (Da)
    58,505
  • Last updated
    2000-10-01 v1
  • Checksum
    6044EC65798DC56B
MGKKGSWFSAIKRVFTPHSKEKQLSNNNQEPEIKSENKEKKKKGFGKKLRNGETNSFLPIFRQPSSIEKILSEAEREHNLVFRPPTPTDRANSSSTSVASPLVRPASPKVPSQRYVSSPKPISPRVAYPQVHYPKPPSPKPPSPRAVSPRIVQRREFVHRPEPSLLVKNAYAIKIQAAFRGYMARRSFRALKGLVRLQGVVRGHSVKRQTMNAMKYMQLLVRVQTQVQSRRIQMLENRARNDKDDTKLVSSRMSDDWDDSVLTKEEKDVRLHRKIDAMIKRERSMAYAYSHQLWKNSPKSAQDIRTSGFPLWWNWVDRQKNQNQPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGGRATQDSPFKDDDSLTSCPPFSAPSYMAPTVSAKAKLRANSNPKERMDRTPVSTNEKRRSSFPLGSFKWNKGSLFMSNNSNNKGPGSSSSGAVVLEKHKTLKSVGNLSIDSTVSMPATIGRRAFNRFA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias32-49Basic and acidic residues
Compositional bias86-102Polar residues
Compositional bias130-146Pro residues
Compositional bias324-390Polar residues
Compositional bias428-444Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL138659
EMBL· GenBank· DDBJ
CAB75466.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE79956.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
ANM64846.1
EMBL· GenBank· DDBJ
Genomic DNA
AY128329
EMBL· GenBank· DDBJ
AAM91532.1
EMBL· GenBank· DDBJ
mRNA
BT001176
EMBL· GenBank· DDBJ
AAN65063.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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