Q9M199 · IQD13_ARATH
- ProteinProtein IQ-DOMAIN 13
- GeneIQD13
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids517 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Regulates the formation of oval xylem secondary cell-wall deposition pits through microtubule-dependent lateral inhibition of Rho GTPase domains, thus confining the area of active ROP domains within the lattice of the cortical microtubules (PubMed:28803875).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Regulates the formation of oval xylem secondary cell-wall deposition pits through microtubule-dependent lateral inhibition of Rho GTPase domains, thus confining the area of active ROP domains within the lattice of the cortical microtubules (PubMed:28803875).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cortical microtubule | |
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Biological Process | plant-type secondary cell wall biogenesis | |
Biological Process | regulation of secondary cell wall biogenesis | |
Biological Process | response to calcium ion | |
Biological Process | xylem development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameProtein IQ-DOMAIN 13
- Short namesAtIQD13
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9M199
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Formation of abnormally large and round secondary cell-wall pits in roots metaxylem vessels (PubMed:28803875).
The double mutant iqd13 iqd14 exhibits larger secondary cell-wall pits (PubMed:28803875).
The double mutant iqd13 iqd14 exhibits larger secondary cell-wall pits (PubMed:28803875).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 44 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000453120 | 1-517 | Protein IQ-DOMAIN 13 | |||
Sequence: MGKKGSWFSAIKRVFTPHSKEKQLSNNNQEPEIKSENKEKKKKGFGKKLRNGETNSFLPIFRQPSSIEKILSEAEREHNLVFRPPTPTDRANSSSTSVASPLVRPASPKVPSQRYVSSPKPISPRVAYPQVHYPKPPSPKPPSPRAVSPRIVQRREFVHRPEPSLLVKNAYAIKIQAAFRGYMARRSFRALKGLVRLQGVVRGHSVKRQTMNAMKYMQLLVRVQTQVQSRRIQMLENRARNDKDDTKLVSSRMSDDWDDSVLTKEEKDVRLHRKIDAMIKRERSMAYAYSHQLWKNSPKSAQDIRTSGFPLWWNWVDRQKNQNQPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGGRATQDSPFKDDDSLTSCPPFSAPSYMAPTVSAKAKLRANSNPKERMDRTPVSTNEKRRSSFPLGSFKWNKGSLFMSNNSNNKGPGSSSSGAVVLEKHKTLKSVGNLSIDSTVSMPATIGRRAFNRFA |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in vessels of roots, cotyledons and leaves, as well as in trichomes.
Developmental stage
In roots, mostly localized to microtubule-like filaments beneath the secondary cell walls of metaxylem cells.
Gene expression databases
Interaction
Subunit
Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-11 | Calmodulin-binding | ||||
Sequence: MGKKGSWFSAI | ||||||
Region | 1-60 | Disordered | ||||
Sequence: MGKKGSWFSAIKRVFTPHSKEKQLSNNNQEPEIKSENKEKKKKGFGKKLRNGETNSFLPI | ||||||
Compositional bias | 32-49 | Basic and acidic residues | ||||
Sequence: EIKSENKEKKKKGFGKKL | ||||||
Region | 81-147 | Disordered | ||||
Sequence: VFRPPTPTDRANSSSTSVASPLVRPASPKVPSQRYVSSPKPISPRVAYPQVHYPKPPSPKPPSPRAV | ||||||
Compositional bias | 86-102 | Polar residues | ||||
Sequence: TPTDRANSSSTSVASPL | ||||||
Compositional bias | 130-146 | Pro residues | ||||
Sequence: QVHYPKPPSPKPPSPRA | ||||||
Domain | 168-196 | IQ 1 | ||||
Sequence: KNAYAIKIQAAFRGYMARRSFRALKGLVR | ||||||
Domain | 197-218 | IQ 2 | ||||
Sequence: LQGVVRGHSVKRQTMNAMKYMQ | ||||||
Compositional bias | 324-390 | Polar residues | ||||
Sequence: QPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGG | ||||||
Region | 324-407 | Disordered | ||||
Sequence: QPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGGRATQDSPFKDDDSLTSC | ||||||
Region | 425-452 | Disordered | ||||
Sequence: KLRANSNPKERMDRTPVSTNEKRRSSFP | ||||||
Compositional bias | 428-444 | Basic and acidic residues | ||||
Sequence: ANSNPKERMDRTPVSTN |
Sequence similarities
Belongs to the IQD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)58,505
- Last updated2000-10-01 v1
- Checksum6044EC65798DC56B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 32-49 | Basic and acidic residues | ||||
Sequence: EIKSENKEKKKKGFGKKL | ||||||
Compositional bias | 86-102 | Polar residues | ||||
Sequence: TPTDRANSSSTSVASPL | ||||||
Compositional bias | 130-146 | Pro residues | ||||
Sequence: QVHYPKPPSPKPPSPRA | ||||||
Compositional bias | 324-390 | Polar residues | ||||
Sequence: QPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGG | ||||||
Compositional bias | 428-444 | Basic and acidic residues | ||||
Sequence: ANSNPKERMDRTPVSTN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL138659 EMBL· GenBank· DDBJ | CAB75466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE79956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | ANM64846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY128329 EMBL· GenBank· DDBJ | AAM91532.1 EMBL· GenBank· DDBJ | mRNA | ||
BT001176 EMBL· GenBank· DDBJ | AAN65063.1 EMBL· GenBank· DDBJ | mRNA |