Q9LZD3 · E70A1_ARATH
- ProteinExocyst complex component EXO70A1
- GeneEXO70A1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids638 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall. Participates in polarized pectin delivery required for the polarized development of the mucilage-producing volcano cells of the seed coat. Involved in the recycling and localization of auxin efflux carriers PIN1 and PIN2, and thus in polar auxin transport regulation. Functions in vesicle trafficking in tracheary elements to regulate patterned secondary cell wall (SCW) thickening (PubMed:27801942).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytoskeleton | |
Cellular Component | cytosol | |
Cellular Component | exocyst | |
Cellular Component | extracellular region | |
Cellular Component | phragmoplast | |
Cellular Component | plasma membrane | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate binding | |
Biological Process | exocytosis | |
Biological Process | protoxylem development | |
Biological Process | regulation of exocyst localization | |
Biological Process | regulation of secondary cell wall biogenesis | |
Biological Process | xylem development | |
Biological Process | xylem vessel member cell differentiation |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameExocyst complex component EXO70A1
- Short namesAtExo70a1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LZD3
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: During cytokinesis, localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall (PubMed:20870962).
Localized at vesicle-like small compartments at cortical microtubules, especially in the presence of FPP3/VETH1, FPP2/VETH2 and COG2 (PubMed:25541219).
Confined to helical/annular plasma membrane (PM) domains in protoxylem of roots before the secondary cell wall (SCW) is deposited. After the induction of xylem differentiation, first associated with plasma membrane (PM) foci and later co-localizes with microtubules (MT) organized into regular bundles, especially at the cell cortex (PubMed:27801942).
Localized at vesicle-like small compartments at cortical microtubules, especially in the presence of FPP3/VETH1, FPP2/VETH2 and COG2 (PubMed:25541219).
Confined to helical/annular plasma membrane (PM) domains in protoxylem of roots before the secondary cell wall (SCW) is deposited. After the induction of xylem differentiation, first associated with plasma membrane (PM) foci and later co-localizes with microtubules (MT) organized into regular bundles, especially at the cell cortex (PubMed:27801942).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Dwarf and sterile plants with decreased apical dominance. Branched inflorescences due to ectopic initiation of lateral inflorescences instead of flowers. Altered polar growth of root hairs and stigmatic papillae. Reduced cell expansion and aberrant xylem development. Aberrant deposition of xylem secondary cell wall (SCW) (PubMed:27801942).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000424565 | 1-638 | Exocyst complex component EXO70A1 | |||
Sequence: MAVDSRMDLLSERAVLMRASLQKSQTITDNVVSILGSFDSRLSALETAMRPTQIRTHAIRKAHENIDRTLKAAEVILSQFDLLRQAETKVLKGPHEDLESYLDAIAQLRKIIRYFMSNKSFKSSDGVLNHANSLLAKAQSKLEEEFKQLLASYSKAVEPDRLFDGLPNSLRPSSDGDGGGKPHGGHHNDDAETAAYTLPILIPSRVLPLLHDLAQQMVQAGHQQQLLQIYRDTRSFVLEESLKKLGVEKLSKEDVQRMQWEVLEAKIGNWIHFMRIAVKLLFAGERQVCDQIFRGFDSLSDQCFAEVTVSSVSMLLSFGDAIARSKRSPEKLFVLLDMYEIMRELHTEIETIFKGKACLEIRDSATGLTKRLAQTAQETFGDFEEAVEKDATKTAVLDGTVHPLTSYVINYVKFLFDYQTTLKQLFLEFGNGDDSNSQLASVTMRIMQALQNNLDGKSKQYKDPALTHLFLMNNIHYMVRSVRRSEAKDLLGDDWVQRHRRIVQQHANQYKRVAWTKILQSSSAQGLTSSGGGSLEGGNSSGVSRGLLKERFKMFNMQFDELHQRQSQWTVPDTELRESLRLAVAEVLLPAYRSFLKRFGPLVESGKNPQKYIKYTAEDLERLLGELFEGKSMNEPRR |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, EXO70A1 and EXO84B. Interacts with SEC3A and EXO84B. Co-localizes with FPP3/VETH1, FPP2/VETH2 and COG2 in vesicle-like small motile compartments (PubMed:25541219).
May interact with COG2 (PubMed:27801942).
May interact with COG2 (PubMed:27801942).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9LZD3 | SEC6 Q94AI6 | 3 | EBI-1797218, EBI-1797182 |
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q9LZD3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length638
- Mass (Da)72,299
- Last updated2000-10-01 v1
- Checksum4660A819EA0C8BB2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL162751 EMBL· GenBank· DDBJ | CAB83315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED90620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY072155 EMBL· GenBank· DDBJ | AAL59977.1 EMBL· GenBank· DDBJ | mRNA | ||
AY133751 EMBL· GenBank· DDBJ | AAM91685.1 EMBL· GenBank· DDBJ | mRNA |