Q9LYU8 · AK1_ARATH

Function

function

Involved in the first step of essential amino acids lysine, threonine, methionine and isoleucine synthesis via the aspartate-family pathway.

Miscellaneous

Only one ACT domain (ACT1) is implicated in effector binding.

Catalytic activity

Activity regulation

Inhibited by S-adenosyl-L-methionine (SAM) and lysine in a synergistic manner. No inhibition by threonine, leucine or SAM alone, and no activation or inhibition by alanine, cysteine, isoleucine, serine, valine, methionine, glutamine, asparagine, glutamic acid or arginine.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
1700 μMATP
2037 μMaspartate
K(cat) is 23.4/sec.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site91ATP (UniProtKB | ChEBI)
Binding site94ATP (UniProtKB | ChEBI)
Binding site123ATP (UniProtKB | ChEBI)
Binding site207substrate
Binding site413L-lysine (UniProtKB | ChEBI); allosteric effector
Binding site415L-lysine (UniProtKB | ChEBI); allosteric effector
Binding site430S-adenosyl-L-methionine (UniProtKB | ChEBI); allosteric effector
Binding site431L-lysine (UniProtKB | ChEBI); allosteric effector
Binding site432L-lysine (UniProtKB | ChEBI); allosteric effector
Binding site437L-lysine (UniProtKB | ChEBI); allosteric effector
Binding site452S-adenosyl-L-methionine (UniProtKB | ChEBI); allosteric effector
Binding site453S-adenosyl-L-methionine (UniProtKB | ChEBI); allosteric effector

GO annotations

AspectTerm
Cellular Componentchloroplast stroma
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Biological Processamino acid biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartokinase 1, chloroplastic
  • EC number
  • Alternative names
    • Aspartate kinase 1

Gene names

    • Name
      AK1
    • Synonyms
      AK, AK-LYS1
    • ORF names
      T31B5.100
    • Ordered locus names
      At5g13280

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9LYU8
  • Secondary accessions
    • O23152

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-90Chloroplast
ChainPRO_000024815791-569Aspartokinase 1, chloroplastic

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain405-483ACT 1
Domain484-560ACT 2

Sequence similarities

Belongs to the aspartokinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    569
  • Mass (Da)
    62,298
  • Last updated
    2000-10-01 v1
  • MD5 Checksum
    7E065E6BBDD5C5196966C22496D613D7
MAATRVRCCHSNAAFTRLPLTRHRNSPTLPISLNRVDFPTLKKLSLPIGDGSSIRKVSGSGSRNIVRAVLEEKKTEAITEVDEKGITCVMKFGGSSVASAERMKEVADLILTFPEESPVIVLSAMGKTTNNLLLAGEKAVSCGVSNASEIEELSIIKELHIRTVKELNIDPSVILTYLEELEQLLKGIAMMKELTLRTRDYLVSFGECLSTRIFAAYLNTIGVKARQYDAFEIGFITTDDFTNGDILEATYPAVAKRLYDDWMHDPAVPIVTGFLGKGWKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKDVDGVLTCDPTIYKRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGEIPVRVKNSYNPKAPGTIITKTRDMTKSILTSIVLKRNVTMLDIASTRMLGQVGFLAKVFSIFEELGISVDVVATSEVSISLTLDPSKLWSRELIQQELDHVVEELEKIAVVNLLKGRAIISLIGNVQHSSLILERAFHVLYTKGVNVQMISQGASKVNISFIVNEAEAEGCVQALHKSFFESGDLSELLIQPRLGNGSPVRTLQVEN

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict369in Ref. 1; CAA67376
Sequence conflict569in Ref. 1; CAA67376

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X98873
EMBL· GenBank· DDBJ
CAA67376.1
EMBL· GenBank· DDBJ
mRNA
AL163491
EMBL· GenBank· DDBJ
CAB86635.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED91874.1
EMBL· GenBank· DDBJ
Genomic DNA
BT000493
EMBL· GenBank· DDBJ
AAN18062.1
EMBL· GenBank· DDBJ
mRNA
AY057674
EMBL· GenBank· DDBJ
AAL15305.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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