Q9LYB9 · MBD4_ARATH

Function

function

Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing.

Features

Showing features for binding site.

118620406080100120140160180
TypeIDPosition(s)Description
Binding site32Zn2+ (UniProtKB | ChEBI)
Binding site35Zn2+ (UniProtKB | ChEBI)
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site69Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthistone deacetylase complex
Cellular Componentnucleus
Molecular Functionmethyl-CpG binding
Molecular Functionzinc ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Methyl-CpG-binding domain-containing protein 4
  • Short names
    AtMBD4; MBD04
  • Alternative names
    • Methyl-CpG-binding protein MBD4

Gene names

    • Name
      MBD4
    • ORF names
      T20O10.130
    • Ordered locus names
      At3g63030

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9LYB9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004052801-186Methyl-CpG-binding domain-containing protein 4

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in rosette leaves, buds, flowers, stems, mature seeds and roots.

Gene expression databases

Interaction

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, motif, domain, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger22-77CW-type
Motif31-69MBD-associated domain (MAD)
Domain83-153MBD
Region154-186Disordered
Compositional bias167-186Polar residues

Domain

The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    21,159
  • Last updated
    2000-10-01 v1
  • Checksum
    754BED4FF0575A8C
MKEEEEIGKPAKPKAKKDVAPGRLIDTYAAQCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSCEEPADIDYDSSRTWVIDKPGLPKTPKGFKRSLVLRKDYSKMDTYYFTPTGKKLRSRNEIAAFVEANPEFRNAPLGDFNFTVPKVMEDTVPPDPKLGSPFPSTTTTTSEKSSVKQSHN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias167-186Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL163816
EMBL· GenBank· DDBJ
CAB87748.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE80426.1
EMBL· GenBank· DDBJ
Genomic DNA
BT010516
EMBL· GenBank· DDBJ
AAQ65139.1
EMBL· GenBank· DDBJ
mRNA
AK176600
EMBL· GenBank· DDBJ
BAD44363.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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