Q9LYB9 · MBD4_ARATH
- ProteinMethyl-CpG-binding domain-containing protein 4
- GeneMBD4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids186 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | histone deacetylase complex | |
Cellular Component | nucleus | |
Molecular Function | methyl-CpG binding | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMethyl-CpG-binding domain-containing protein 4
- Short namesAtMBD4; MBD04
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LYB9
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405280 | 1-186 | Methyl-CpG-binding domain-containing protein 4 | |||
Sequence: MKEEEEIGKPAKPKAKKDVAPGRLIDTYAAQCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSCEEPADIDYDSSRTWVIDKPGLPKTPKGFKRSLVLRKDYSKMDTYYFTPTGKKLRSRNEIAAFVEANPEFRNAPLGDFNFTVPKVMEDTVPPDPKLGSPFPSTTTTTSEKSSVKQSHN |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in rosette leaves, buds, flowers, stems, mature seeds and roots.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9LYB9 | At4g35610 O81793 | 5 | EBI-15191715, EBI-15191765 | |
BINARY | Q9LYB9 | At5g28040 F4K5T4 | 3 | EBI-15191715, EBI-15193831 | |
BINARY | Q9LYB9 | DAZ3 O81801 | 5 | EBI-15191715, EBI-4447483 | |
BINARY | Q9LYB9 | IAA2 P49678 | 4 | EBI-15191715, EBI-632343 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, motif, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 22-77 | CW-type | ||||
Sequence: GRLIDTYAAQCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSCEEPADIDY | ||||||
Motif | 31-69 | MBD-associated domain (MAD) | ||||
Sequence: QCDNCHKWRVIDSQEEYEDIRSKMLEDPFNCQKKQGMSC | ||||||
Domain | 83-153 | MBD | ||||
Sequence: WVIDKPGLPKTPKGFKRSLVLRKDYSKMDTYYFTPTGKKLRSRNEIAAFVEANPEFRNAPLGDFNFTVPKV | ||||||
Region | 154-186 | Disordered | ||||
Sequence: MEDTVPPDPKLGSPFPSTTTTTSEKSSVKQSHN | ||||||
Compositional bias | 167-186 | Polar residues | ||||
Sequence: PFPSTTTTTSEKSSVKQSHN |
Domain
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length186
- Mass (Da)21,159
- Last updated2000-10-01 v1
- Checksum754BED4FF0575A8C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 167-186 | Polar residues | ||||
Sequence: PFPSTTTTTSEKSSVKQSHN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL163816 EMBL· GenBank· DDBJ | CAB87748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE80426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT010516 EMBL· GenBank· DDBJ | AAQ65139.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176600 EMBL· GenBank· DDBJ | BAD44363.1 EMBL· GenBank· DDBJ | mRNA |