Q9LV85 · CPR5_ARATH
- ProteinProtein CPR-5
- GeneCPR5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids564 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Negatively regulates the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd) (PubMed:11728314, PubMed:11846876, PubMed:9338960, Ref.6). Negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (PubMed:25455564).
Promotes cell division and endoreduplication (e.g. in trichomes) (PubMed:11728314).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Cellular Component | nuclear envelope | |
Cellular Component | nuclear membrane | |
Cellular Component | nucleus | |
Biological Process | defense response | |
Biological Process | leaf senescence | |
Biological Process | photoperiodism, flowering | |
Biological Process | response to ethylene | |
Biological Process | sugar mediated signaling pathway | |
Biological Process | systemic acquired resistance | |
Biological Process | trichome morphogenesis |
Protein family/group databases
Is an RNA-binding protein controlling plant immunity via an RNA processing complex. Induces basal immunity against Pseudomonas syringae pv. maculicola (Psm).
A plant-specific transmembrane nucleoporin. Aassociates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC.
Names & Taxonomy
Protein names
- Recommended nameProtein CPR-5
- Alternative names
Gene names
- Community suggested namesCPR5
- Community suggested namesCPR5
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LV85
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 347-367 | Helical | ||||
Sequence: IMDWLLVSVFSMLASMVLGVY | ||||||
Transmembrane | 411-431 | Helical | ||||
Sequence: VRVWVQIFFGVLMIIVFTYFL | ||||||
Transmembrane | 443-463 | Helical | ||||
Sequence: PISFIVLFLGIFCGVSGKLCV | ||||||
Transmembrane | 472-492 | Helical | ||||
Sequence: LWLIVWEVFCLLQFVANVFTL | ||||||
Transmembrane | 526-546 | Helical | ||||
Sequence: VYVVILFVLPVINGLLPFATF |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 535 | In hys1-2; early senescence, enhanced chlorosis, hypersensitivity to sugars-mediated growth inhibition, and abnormal trichomes. | ||||
Sequence: P → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 36 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000244568 | 1-564 | Protein CPR-5 | |||
Sequence: MEALLLPPSPEPQNQITNPANSKPNHQSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDNDEASSSYCSTSSTSNSNSTKRVTRVVHRLRNPMRLGMARRSVGERQAEKLAKPLGFSLAAFANMVIARKNAAGQNVYVDDLVEIFATLVEESLANVYGNKLGSFATNFEQTFSSTLKILKLTNECANPHQSNNNDGGSCNLDRSTIDGCSDTELFERETSSATSAYEVMQGSATATSLMNELALFEETLQLSCVPPRSSAMALTTDERFLKEQTRANDLKTVEIGLQIRELRCKETALGLKFESNNLGKAALELDVSKAAFRAEKFKTELEDTRKEEMVTRIMDWLLVSVFSMLASMVLGVYNFSIKRIEDATSVCDQSEEKSSSWWVPKQVSSINSGFNTFICRVRVWVQIFFGVLMIIVFTYFLNKRSSGTKQTMPISFIVLFLGIFCGVSGKLCVDTLGGDGKLWLIVWEVFCLLQFVANVFTLALYGLMFGPINVTQETRSNRCNSMFPYWARRSVVYVVILFVLPVINGLLPFATFGEWRDFAMYHLHGGSDYA |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-87 | Disordered | ||||
Sequence: MEALLLPPSPEPQNQITNPANSKPNHQSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDNDEASSSYCSTSSTSNSNSTKRV | ||||||
Compositional bias | 27-66 | Basic and acidic residues | ||||
Sequence: QSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDND | ||||||
Compositional bias | 67-87 | Polar residues | ||||
Sequence: EASSSYCSTSSTSNSNSTKRV |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length564
- Mass (Da)63,112
- Last updated2000-10-01 v1
- ChecksumE3034C6311AEA07C
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-66 | Basic and acidic residues | ||||
Sequence: QSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDND | ||||||
Compositional bias | 67-87 | Polar residues | ||||
Sequence: EASSSYCSTSSTSNSNSTKRV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB063329 EMBL· GenBank· DDBJ | BAB79495.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AB019236 EMBL· GenBank· DDBJ | BAA97305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY033229 EMBL· GenBank· DDBJ | AAK56393.1 EMBL· GenBank· DDBJ | mRNA |