Q9LJD7 · COP10_ARATH

Function

function

Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1. Although strongly related to ubiquitin-conjugating enzyme, it has no catalytic activity by itself due to the absence of the conserved Cys active site at position 120. It can however enhance the activity of E2 conjugating enzymes.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionubiquitin-protein transferase activity
Biological Processred, far-red light phototransduction
Biological Processregulation of photomorphogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Constitutive photomorphogenesis protein 10

Gene names

    • Name
      COP10
    • ORF names
      MRP15.21
    • Ordered locus names
      At3g13550

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9LJD7
  • Secondary accessions
    • A0A178VI85
    • Q0WNL1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis78In COP10-4; induces an open cotyledon phenotype due to defects in photomorphogenic repression.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000826111-182Constitutive photomorphogenesis protein 10

Proteomic databases

Expression

Tissue specificity

Expressed in flower, leaf, stem and seedling. Expressed at lower level in root.

Gene expression databases

Interaction

Subunit

Component of the CDD complex, at least composed of COP10, DET1 and DDB1A (PubMed:15342494, PubMed:24563205).
Interacts with E3 ubiquitin ligase COP1. Interacts with E2 ubiquitin conjugating UBC5. Interacts with CSN3, CSN4 and CSN8 subunits of the COP9 complex

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9LJD7COP1 P432543EBI-2429853, EBI-301649
BINARY Q9LJD7CUL4 Q8LGH44EBI-2429853, EBI-541750
BINARY Q9LJD7DDB1A Q9M0V35EBI-2429853, EBI-1632780

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-182UBC core

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

Q9LJD7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    182
  • Mass (Da)
    20,130
  • Last updated
    2000-10-01 v1
  • Checksum
    6F255A398ECE901E
MMTPGGSGRLRPLPTAMYAGYSGTASSWVAKTSVSASGKRIQREMAELNIDPPPDCSAGPKGDNLYHWIATIIGPSGTPYEGGIFFLDIIFPSDYPFKPPKLVFKTRIYHCNVDTAGDLSVNILRDSWSPALTITKVLQAIRSIFLKPEPYSPALPVIARLYLTDREKHDEVAKEWTLRFAK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B9DGC9B9DGC9_ARATHFUS9170

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY034618
EMBL· GenBank· DDBJ
AAK57749.1
EMBL· GenBank· DDBJ
mRNA
AP000603
EMBL· GenBank· DDBJ
BAB01762.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE75370.1
EMBL· GenBank· DDBJ
Genomic DNA
AK229428
EMBL· GenBank· DDBJ
BAF01288.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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