Q9LJD7 · COP10_ARATH
- ProteinConstitutive photomorphogenesis protein 10
- GeneCOP10
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids182 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1. Although strongly related to ubiquitin-conjugating enzyme, it has no catalytic activity by itself due to the absence of the conserved Cys active site at position 120. It can however enhance the activity of E2 conjugating enzymes.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ubiquitin-protein transferase activity | |
Biological Process | red, far-red light phototransduction | |
Biological Process | regulation of photomorphogenesis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameConstitutive photomorphogenesis protein 10
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LJD7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 78 | In COP10-4; induces an open cotyledon phenotype due to defects in photomorphogenic repression. | ||||
Sequence: T → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082611 | 1-182 | Constitutive photomorphogenesis protein 10 | |||
Sequence: MMTPGGSGRLRPLPTAMYAGYSGTASSWVAKTSVSASGKRIQREMAELNIDPPPDCSAGPKGDNLYHWIATIIGPSGTPYEGGIFFLDIIFPSDYPFKPPKLVFKTRIYHCNVDTAGDLSVNILRDSWSPALTITKVLQAIRSIFLKPEPYSPALPVIARLYLTDREKHDEVAKEWTLRFAK |
Proteomic databases
Expression
Tissue specificity
Expressed in flower, leaf, stem and seedling. Expressed at lower level in root.
Gene expression databases
Interaction
Subunit
Component of the CDD complex, at least composed of COP10, DET1 and DDB1A (PubMed:15342494, PubMed:24563205).
Interacts with E3 ubiquitin ligase COP1. Interacts with E2 ubiquitin conjugating UBC5. Interacts with CSN3, CSN4 and CSN8 subunits of the COP9 complex
Interacts with E3 ubiquitin ligase COP1. Interacts with E2 ubiquitin conjugating UBC5. Interacts with CSN3, CSN4 and CSN8 subunits of the COP9 complex
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9LJD7 | COP1 P43254 | 3 | EBI-2429853, EBI-301649 | |
BINARY | Q9LJD7 | CUL4 Q8LGH4 | 4 | EBI-2429853, EBI-541750 | |
BINARY | Q9LJD7 | DDB1A Q9M0V3 | 5 | EBI-2429853, EBI-1632780 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-182 | UBC core | ||||
Sequence: ASGKRIQREMAELNIDPPPDCSAGPKGDNLYHWIATIIGPSGTPYEGGIFFLDIIFPSDYPFKPPKLVFKTRIYHCNVDTAGDLSVNILRDSWSPALTITKVLQAIRSIFLKPEPYSPALPVIARLYLTDREKHDEVAKEWTLRFAK |
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q9LJD7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length182
- Mass (Da)20,130
- Last updated2000-10-01 v1
- Checksum6F255A398ECE901E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B9DGC9 | B9DGC9_ARATH | FUS9 | 170 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY034618 EMBL· GenBank· DDBJ | AAK57749.1 EMBL· GenBank· DDBJ | mRNA | ||
AP000603 EMBL· GenBank· DDBJ | BAB01762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE75370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK229428 EMBL· GenBank· DDBJ | BAF01288.1 EMBL· GenBank· DDBJ | mRNA |