Q9LIS3 · GAE6_ARATH
- ProteinUDP-glucuronate 4-epimerase 6
- GeneGAE6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids460 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.
Catalytic activity
- UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.23 mM | UDP-glucuronate |
No activity with UDP-Galactose, UDP- Glucose or UDP-Xylose.
pH Dependence
Optimum pH is 7.9. Active from pH 6 to 8.9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 113-144 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 263 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi cisterna membrane | |
Cellular Component | Golgi trans cisterna | |
Cellular Component | trans-Golgi network | |
Molecular Function | UDP-glucuronate 4-epimerase activity | |
Biological Process | defense response to fungus | |
Biological Process | defense response to Gram-negative bacterium | |
Biological Process | galacturonate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucuronate 4-epimerase 6
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LIS3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 41-61 | Helical | |||
Transmembrane | 111-131 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000292601 | 1-460 | UDP-glucuronate 4-epimerase 6 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
In roots, leaf veins, siliques, flowers, pollen and stems.
Gene expression databases
Interaction
Subunit
Homodimer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9LIS3 | CPK4 Q38869 | 4 | EBI-2297116, EBI-979475 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length460
- Mass (Da)50,570
- Last updated2000-10-01 v1
- MD5 Checksum7B2F7E66ABD551C2AA9EC66585D5320F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ879893 EMBL· GenBank· DDBJ | CAI53858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP001297 EMBL· GenBank· DDBJ | BAB03000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE76818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF083691 EMBL· GenBank· DDBJ | AAN60250.1 EMBL· GenBank· DDBJ | mRNA | ||
AF370210 EMBL· GenBank· DDBJ | AAK44025.1 EMBL· GenBank· DDBJ | mRNA | ||
AY056117 EMBL· GenBank· DDBJ | AAL07003.1 EMBL· GenBank· DDBJ | mRNA | ||
AY062625 EMBL· GenBank· DDBJ | AAL32703.1 EMBL· GenBank· DDBJ | mRNA | ||
AY133771 EMBL· GenBank· DDBJ | AAM91705.1 EMBL· GenBank· DDBJ | mRNA |