Q9LIK7 · ACA13_ARATH
- ProteinPutative calcium-transporting ATPase 13, plasma membrane-type
- GeneACA13
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1017 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.
Catalytic activity
- ATP + Ca2+(in) + H2O = ADP + Ca2+(out) + H+ + phosphate
CHEBI:30616 + Ca2+ (in)CHEBI:29108+ CHEBI:15377 = CHEBI:456216 + Ca2+ (out)CHEBI:29108+ CHEBI:15378 + CHEBI:43474
Activity regulation
Activated by calmodulin.
Features
Showing features for active site, binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | calmodulin binding | |
Molecular Function | metal ion binding | |
Molecular Function | P-type calcium transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative calcium-transporting ATPase 13, plasma membrane-type
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LIK7
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-147 | Cytoplasmic | ||||
Sequence: MRRNVSDHAEKKDKVGVEVLLELPKTLSKSNKKWQLALIKLYCSRTLLNCAKHAIRKPGLFPRSLSYTAIDLDHHHGDDHFKIDTETLNDLVKNKNQEKLESLGGPNGLVSALKSNTRLGINEEGDEIQRRRSTFGSNTYTRQPSKG | ||||||
Transmembrane | 148-168 | Helical | ||||
Sequence: LFHFVVEAFKDLTILILLGCA | ||||||
Topological domain | 169-186 | Lumenal | ||||
Sequence: TLSLGFGIKEHGLKEGWY | ||||||
Transmembrane | 187-207 | Helical | ||||
Sequence: DGGSIFVAVFLVVAVSAVSNF | ||||||
Topological domain | 208-336 | Cytoplasmic | ||||
Sequence: RQNRQFDKLSKVSSNIKIDVVRNGRRQEISIFDIVVGDIVCLNIGDQVPADGVFVEGHLLHVDESSMTGESDHVEVSLTGNTFLFSGTKIADGFGKMAVTSVGMNTAWGQMMSHISRDTNEQTPLQSRL | ||||||
Transmembrane | 337-356 | Helical | ||||
Sequence: DKLTSSIGKVGLLVAFLVLL | ||||||
Topological domain | 357-393 | Lumenal | ||||
Sequence: VLLIRYFTGTTKDESGNREYNGKTTKSDEIVNAVVKM | ||||||
Transmembrane | 394-411 | Helical | ||||
Sequence: VAAAVTIIVVAIPEGLPL | ||||||
Topological domain | 412-802 | Cytoplasmic | ||||
Sequence: AVTLTLAYSMKRMMKDNAMVRKLSACETMGSATVICTDKTGTLTLNQMKVTDFWFGLESGKASSVSQRVVELFHQGVAMNTTGSVFKAKAGTEYEFSGSPTEKAILSWAVEELEMGMEKVIEEHDVVHVEGFNSEKKRSGVLMKKKGVNTENNVVHWKGAAEKILAMCSTFCDGSGVVREMKEDDKIQFEKIIQSMAAKSLRCIAFAYSEDNEDNKKLKEEKLSLLGIIGIKDPCRPGVKKAVEDCQFAGVNIKMITGDNIFTARAIAVECGILTPEDEMNSEAVLEGEKFRNYTQEERLEKVERIKVMARSSPFDKLLMVKCLKELGHVVAVTGDGTNDAPALKEADIGLSMGIQGTEVAKESSDIVILDDNFASVATVLKWGRCVYNNI | ||||||
Transmembrane | 803-821 | Helical | ||||
Sequence: QKFIQFQLTVNVAALVINF | ||||||
Topological domain | 822-832 | Lumenal | ||||
Sequence: VAAVSAGDVPL | ||||||
Transmembrane | 833-853 | Helical | ||||
Sequence: TAVQLLWVNLIMDTLGALALA | ||||||
Topological domain | 854-873 | Cytoplasmic | ||||
Sequence: TEKPTNDLMKKKPIGRVAPL | ||||||
Transmembrane | 874-896 | Helical | ||||
Sequence: ITNIMWRNLLAQAFYQISVLLVL | ||||||
Topological domain | 897-905 | Lumenal | ||||
Sequence: QFRGRSIFN | ||||||
Transmembrane | 906-926 | Helical | ||||
Sequence: VTEKVKNTLIFNTFVLCQVFN | ||||||
Topological domain | 927-944 | Cytoplasmic | ||||
Sequence: EFNARSLEKKNVFKGLHK | ||||||
Transmembrane | 945-966 | Helical | ||||
Sequence: NRLFIGIIVVTVVLQVVMVEFL | ||||||
Topological domain | 967-976 | Lumenal | ||||
Sequence: KRFADTERLN | ||||||
Transmembrane | 977-998 | Helical | ||||
Sequence: LGQWGVCIAIAAASWPIGWLVK | ||||||
Topological domain | 999-1002 | Cytoplasmic | ||||
Sequence: SVPV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000046419 | 1-1017 | Putative calcium-transporting ATPase 13, plasma membrane-type | |||
Sequence: MRRNVSDHAEKKDKVGVEVLLELPKTLSKSNKKWQLALIKLYCSRTLLNCAKHAIRKPGLFPRSLSYTAIDLDHHHGDDHFKIDTETLNDLVKNKNQEKLESLGGPNGLVSALKSNTRLGINEEGDEIQRRRSTFGSNTYTRQPSKGLFHFVVEAFKDLTILILLGCATLSLGFGIKEHGLKEGWYDGGSIFVAVFLVVAVSAVSNFRQNRQFDKLSKVSSNIKIDVVRNGRRQEISIFDIVVGDIVCLNIGDQVPADGVFVEGHLLHVDESSMTGESDHVEVSLTGNTFLFSGTKIADGFGKMAVTSVGMNTAWGQMMSHISRDTNEQTPLQSRLDKLTSSIGKVGLLVAFLVLLVLLIRYFTGTTKDESGNREYNGKTTKSDEIVNAVVKMVAAAVTIIVVAIPEGLPLAVTLTLAYSMKRMMKDNAMVRKLSACETMGSATVICTDKTGTLTLNQMKVTDFWFGLESGKASSVSQRVVELFHQGVAMNTTGSVFKAKAGTEYEFSGSPTEKAILSWAVEELEMGMEKVIEEHDVVHVEGFNSEKKRSGVLMKKKGVNTENNVVHWKGAAEKILAMCSTFCDGSGVVREMKEDDKIQFEKIIQSMAAKSLRCIAFAYSEDNEDNKKLKEEKLSLLGIIGIKDPCRPGVKKAVEDCQFAGVNIKMITGDNIFTARAIAVECGILTPEDEMNSEAVLEGEKFRNYTQEERLEKVERIKVMARSSPFDKLLMVKCLKELGHVVAVTGDGTNDAPALKEADIGLSMGIQGTEVAKESSDIVILDDNFASVATVLKWGRCVYNNIQKFIQFQLTVNVAALVINFVAAVSAGDVPLTAVQLLWVNLIMDTLGALALATEKPTNDLMKKKPIGRVAPLITNIMWRNLLAQAFYQISVLLVLQFRGRSIFNVTEKVKNTLIFNTFVLCQVFNEFNARSLEKKNVFKGLHKNRLFIGIIVVTVVLQVVMVEFLKRFADTERLNLGQWGVCIAIAAASWPIGWLVKSVPVPERHFFSYLKWKKRS |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-31 | Interaction with calmodulin | ||||
Sequence: LLELPKTLSKSN |
Domain
The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,017
- Mass (Da)112,528
- Last updated2000-10-01 v1
- Checksum2F0265CCE8862916
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP001300 EMBL· GenBank· DDBJ | BAB03036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE76690.1 EMBL· GenBank· DDBJ | Genomic DNA |