Q9LEI9 · ENO2_HEVBR
- ProteinEnolase 2
- GeneENO2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids445 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
Cofactor
Note: Mg2+ is required for catalysis and for stabilizing the dimer.
Pathway
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 164 | substrate | |||
Binding site | 173 | substrate | |||
Active site | 216 | Proton donor | |||
Binding site | 251 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 301 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 301 | substrate | |||
Binding site | 328 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 328 | substrate | |||
Active site | 353 | Proton acceptor | |||
Binding site | 380-383 | substrate | |||
Binding site | 404 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | phosphopyruvate hydratase complex | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphopyruvate hydratase activity | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEnolase 2
- EC number
- Alternative names
- Allergen nameHev b 9
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Malpighiales > Euphorbiaceae > Crotonoideae > Micrandreae > Hevea
Accessions
- Primary accessionQ9LEI9
Subcellular Location
Phenotypes & Variants
Allergenic properties
Causes an allergic reaction in human. Involved in latex allergic reactions.
Keywords
- Disease
Protein family/group databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000134070 | 1-445 | Enolase 2 | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length445
- Mass (Da)47,914
- Last updated2000-10-01 v1
- ChecksumC5B42954F0E83EC8
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ132581 EMBL· GenBank· DDBJ | CAC00533.1 EMBL· GenBank· DDBJ | mRNA |