Q9LE82 · RAGP1_ARATH
- ProteinRAN GTPase-activating protein 1
- GeneRANGAP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids535 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Plays a role in spatial signaling during cell division.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell division site | |
Cellular Component | cell plate | |
Cellular Component | cytosol | |
Cellular Component | nuclear envelope | |
Cellular Component | nuclear membrane | |
Cellular Component | phragmoplast | |
Cellular Component | spindle | |
Molecular Function | GTPase activator activity | |
Biological Process | cytokinesis by cell plate formation | |
Biological Process | protein import into nucleus |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameRAN GTPase-activating protein 1
- Short namesAtRanGAP1; RanGAP1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9LE82
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Nucleus membrane ; Peripheral membrane protein
Note: Localized in patchy areas at the nuclear envelope (NE) of interphase cells. Concentrates at the preprophase band (PPB) and remains associated with the cortical division site (CDS) during mitosis and cytokinesis. During mitosis, associates with mitotic spindles at the anaphase. Associated to the microtubular phragmoplast and the surface of the daughter nuclei at the telophase.
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 18-19 | Loss of nuclear envelope localization. | ||||
Sequence: WP → AA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000347214 | 1-535 | RAN GTPase-activating protein 1 | |||
Sequence: MDHSAKTTQNRVLSVKMWPPSKSTRLMLVERMTKNITTPSIFSRKYGLLSVEEAEQDAKRIEDLAFATANKHFQNEPDGDGTSAVHVYAKESSKLMLDVIKRGPQEESEVEVSKDGDVFFDISGGSRAFIEEEEARDLLRPLADPRNSYTKIRFSNRSFGSEAAKFAASVLSSIKDQLTEVDLSDFVAGRPEAEALEVMNMFSSALEGSKLRYLNLSDNALGEKGIRAFASLINSQHDLEELYLMNDGISEDAARAVRELLPSTDKIRVLQFHNNMTGDEGATAIAEIVRECPSLEDFRCSSTRIGSEGGVALAEALEHCSHLKKLDLRDNMFGVEGGIALAKTLSVLTHLTEIYMSYLNLEDEGTEALSEALLKSAPSLEVLELAGNDITVKSTGNLAACIASKQSLAKLNLSENELKDEGTILIAKAVEGHDQLVEVDLSTNMIRRAGARALAQTVVKKNTFKLLNINGNFISEEGIDEVNDMFKDCLDKLVPLDDNDPEGEDFEDEDEEEEGEDGNELESKLGSLKIKQGEE |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer (By similarity).
Interacts with WIP1 through its WPP domain. Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3. Interacts directly with WIT1, WIP2 and WIP3. Interacts with POK1
Interacts with WIP1 through its WPP domain. Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3. Interacts directly with WIT1, WIP2 and WIP3. Interacts with POK1
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9LE82 | KIN12C Q27IK7 | 2 | EBI-1779351, EBI-6881384 | |
BINARY | Q9LE82 | WIP1 Q8GXA4 | 6 | EBI-1779351, EBI-1779367 | |
BINARY | Q9LE82 | WIT1 Q8L7E5 | 5 | EBI-1779351, EBI-1796628 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-115 | WPP | ||||
Sequence: MDHSAKTTQNRVLSVKMWPPSKSTRLMLVERMTKNITTPSIFSRKYGLLSVEEAEQDAKRIEDLAFATANKHFQNEPDGDGTSAVHVYAKESSKLMLDVIKRGPQEESEVEVSKD | ||||||
Repeat | 208-231 | LRR 1 | ||||
Sequence: GSKLRYLNLSDNALGEKGIRAFAS | ||||||
Repeat | 236-259 | LRR 2 | ||||
Sequence: QHDLEELYLMNDGISEDAARAVRE | ||||||
Repeat | 264-287 | LRR 3 | ||||
Sequence: TDKIRVLQFHNNMTGDEGATAIAE | ||||||
Repeat | 320-343 | LRR 4 | ||||
Sequence: CSHLKKLDLRDNMFGVEGGIALAK | ||||||
Repeat | 353-376 | LRR 5 | ||||
Sequence: EIYMSYLNLEDEGTEALSEALLKS | ||||||
Repeat | 377-400 | LRR 6 | ||||
Sequence: APSLEVLELAGNDITVKSTGNLAA | ||||||
Repeat | 405-428 | LRR 7 | ||||
Sequence: KQSLAKLNLSENELKDEGTILIAK | ||||||
Repeat | 433-456 | LRR 8 | ||||
Sequence: HDQLVEVDLSTNMIRRAGARALAQ | ||||||
Repeat | 461-488 | LRR 9 | ||||
Sequence: KNTFKLLNINGNFISEEGIDEVNDMFKD | ||||||
Region | 493-535 | Disordered | ||||
Sequence: LVPLDDNDPEGEDFEDEDEEEEGEDGNELESKLGSLKIKQGEE | ||||||
Compositional bias | 500-519 | Acidic residues | ||||
Sequence: DPEGEDFEDEDEEEEGEDGN | ||||||
Compositional bias | 520-535 | Basic and acidic residues | ||||
Sequence: ELESKLGSLKIKQGEE |
Domain
The WPP domain is required for the nuclear envelope localization.
Sequence similarities
Belongs to the RNA1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length535
- Mass (Da)58,827
- Last updated2000-10-01 v1
- Checksum06CA71980A007BEB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 500-519 | Acidic residues | ||||
Sequence: DPEGEDFEDEDEEEEGEDGN | ||||||
Compositional bias | 520-535 | Basic and acidic residues | ||||
Sequence: ELESKLGSLKIKQGEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF214559 EMBL· GenBank· DDBJ | AAF25947.1 EMBL· GenBank· DDBJ | mRNA | ||
AL163816 EMBL· GenBank· DDBJ | CAB87758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE80438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE80439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY034918 EMBL· GenBank· DDBJ | AAK59425.1 EMBL· GenBank· DDBJ | mRNA | ||
AY150448 EMBL· GenBank· DDBJ | AAN12889.1 EMBL· GenBank· DDBJ | mRNA |