Q9LAM9 · MSRAB_STRGC

Function

function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
Involved in protection against oxidative stress when the bacterium enters the host bloodstream and required for maximal growth under aerobic and anaerobic conditions

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site10
Active site284Nucleophile

GO annotations

AspectTerm
Molecular FunctionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Molecular Functionpeptide-methionine (S)-S-oxide reductase activity
Biological Processprotein modification process
Biological Processprotein repair
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptide methionine sulfoxide reductase MsrA/MsrB

Including 2 domains:

  • Recommended name
    Peptide methionine sulfoxide reductase MsrA
  • EC number
  • Short names
    Protein-methionine-S-oxide reductase
  • Alternative names
    • Peptide-methionine (S)-S-oxide reductase (Peptide Met(O) reductase)
  • Recommended name
    Peptide methionine sulfoxide reductase MsrB
  • EC number
  • Alternative names
    • Peptide-methionine (R)-S-oxide reductase

Gene names

    • Name
      msrAB
    • Synonyms
      msrA
    • Ordered locus names
      SGO_0278

Organism names

Accessions

  • Primary accession
    Q9LAM9
  • Secondary accessions
    • A8AUY7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001385161-311Peptide methionine sulfoxide reductase MsrA/MsrB

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-155Peptide methionine sulfoxide reductase A
Domain172-295MsrB

Sequence similarities

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    311
  • Mass (Da)
    35,672
  • Last updated
    2000-10-01 v1
  • Checksum
    7D4B7CAF81DBE692
MAEIYLAGGCFWGLEEYFSRIEGVKKTTVGYANGQVESTNYQLIHQTDHAETVHLIYDEKRVSLREILLYYFRVIDPLSVNKQGNDVGRQYRTGVYYTNQADKAVIEQVFAEQEKQLGQKIAVELEPLRHYVLAEDYHQDYLKKNPGGYCHINVNDAYQPLVDPGQYEKPTDAELKEQLTQEQYQVTQLSATERPFHNAYNATFEEGIYVDVTTGEPLFFAGDKFESGCGWPSFSRPIAREVLRYYEDKSHGMERIEVRSRSGNAHLGHVFTDGPESAGGLRYCINSAALRFIPKEKMEAEGYAYLLQHMK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF128264
EMBL· GenBank· DDBJ
AAF36477.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000725
EMBL· GenBank· DDBJ
ABV11083.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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