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Q9L4P1 · LEXA_STAAC

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

120720406080100120140160180200
Type
IDPosition(s)Description
DNA binding28-48H-T-H motif
Site93-94Cleavage; by autolysis
Active site130For autocatalytic cleavage activity
Active site168For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • Ordered locus names
      SACOL1374

Organism names

Accessions

  • Primary accession
    Q9L4P1
  • Secondary accessions
    • Q5HG80

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001700871-207LexA repressor

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    23,301
  • Last updated
    2005-03-15 v3
  • MD5 Checksum
    90844C03DC1A3673448A1CD84E8E06EF
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM

Sequence caution

The sequence CAB82463.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict176in Ref. 1; CAB82463

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ132348
EMBL· GenBank· DDBJ
CAB82463.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
CP000046
EMBL· GenBank· DDBJ
AAW36623.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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