Q9L4P1 · LEXA_STAAC
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids207 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 28-48 | H-T-H motif | |||
Site | 93-94 | Cleavage; by autolysis | |||
Active site | 130 | For autocatalytic cleavage activity | |||
Active site | 168 | For autocatalytic cleavage activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ9L4P1
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000170087 | 1-207 | LexA repressor | ||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length207
- Mass (Da)23,301
- Last updated2005-03-15 v3
- MD5 Checksum90844C03DC1A3673448A1CD84E8E06EF
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 176 | in Ref. 1; CAB82463 | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ132348 EMBL· GenBank· DDBJ | CAB82463.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
CP000046 EMBL· GenBank· DDBJ | AAW36623.1 EMBL· GenBank· DDBJ | Genomic DNA |