Q9KWH3 · DPS_STRMG

  • Protein
    DNA protection during starvation protein
  • Gene
    dps
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral (By similarity).
It binds and incorporates Fe2+ ion. Effectively inhibits hydroxyl radical formation by the Fenton reaction and is essential for colony formation in the presence of air. Is also able to bind zinc ion. Does not bind DNA.

Catalytic activity

Features

Showing features for binding site.

117520406080100120140160
TypeIDPosition(s)Description
Binding site50Fe cation 1 (UniProtKB | ChEBI); ligand shared between two dodecameric partners
Binding site77Fe cation 1 (UniProtKB | ChEBI); ligand shared between two dodecameric partners; in other chain
Binding site81Fe cation 1 (UniProtKB | ChEBI); ligand shared between two dodecameric partners; in other chain
Binding site81Fe cation 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionferric iron binding
Molecular Functionoxidoreductase activity, acting on metal ions
Biological Processintracellular iron ion homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA protection during starvation protein
  • EC number

Gene names

    • Name
      dps
    • ORF names
      dpr/ORF 1

Organism names

  • Taxonomic identifier
  • Strain
    • GS-5
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    Q9KWH3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00002533362-175DNA protection during starvation protein

Expression

Induction

Induced by air.

Interaction

Subunit

Homododecamer (Probable). The oligomer forms a hollow sphere and can store up to 480 Fe3+.

Structure

Family & Domains

Domain

12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes.

Sequence similarities

Belongs to the Dps family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    175
  • Mass (Da)
    19,617
  • Last updated
    2007-01-23 v3
  • Checksum
    0025527959B658A6
MTNTITENIYASIIHQVEKKENSGNEKTKAVLNQAVADLSKAASIVHQVHWYMRGSGFLYLHPKMDELMDALNGHLDEISERLITIGGAPFSTLKEFDENSRLEETVGTWDKSITDHLKRLVQVYDYLSSLYQVGLDVTDEEDDAVSNDIFTAAQTEAQKTIWMLQAELGQAPGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB036428
EMBL· GenBank· DDBJ
BAA96472.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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