Q9KPY2 · GMHA_VIBCH

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LPS core biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site52-54substrate
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site65substrate
Binding site65Zn2+ (UniProtKB | ChEBI)
Binding site93-94substrate
Binding site119-121substrate
Binding site124substrate
Binding site172substrate
Binding site172Zn2+ (UniProtKB | ChEBI)
Binding site180Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • Ordered locus names
      VC_2230

Organism names

Accessions

  • Primary accession
    Q9KPY2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001365481-191Phosphoheptose isomerase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-191SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    20,646
  • Last updated
    2000-10-01 v1
  • Checksum
    B5A57D89F437FED0
MYQDLIRSELTEAADVLQKFLSDDHNIAQIEAAAKLIADSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPGIAISDPSHLSCVSNDFGYDYVFSRYVEAVGAKGDVLFGLSTSGNSGNILKAIEAAKAKGMKTIALTGKDGGKMAGLADVEIRVPHFGYADRIQEVHIKIIHIIIQLIEKEMA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE003852
EMBL· GenBank· DDBJ
AAF95374.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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