Q9KJA7 · BLAB8_ELIME

Function

function

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site97Zn2+ 1 (UniProtKB | ChEBI)
Binding site99Zn2+ 1 (UniProtKB | ChEBI)
Binding site101Zn2+ 2 (UniProtKB | ChEBI)
Binding site160Zn2+ 1 (UniProtKB | ChEBI)
Binding site179Zn2+ 2 (UniProtKB | ChEBI)
Binding site182substrate
Binding site221Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperiplasmic space
Molecular Functionbeta-lactamase activity
Molecular Functionzinc ion binding
Biological Processantibiotic catabolic process
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metallo-beta-lactamase type 2
  • EC number
  • Alternative names
    • B2 metallo-beta-lactamase
    • Beta-lactamase type II
    • Carbapenem-hydrolyzing beta-lactamase BlaB-8
      (CHbetaL-8
      )
    • Class B carbapenemase BlaB-8
    • Metallo-beta-lactamase type II

Gene names

    • Name
      blaB8
    • Synonyms
      blaB

Organism names

Accessions

  • Primary accession
    Q9KJA7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000001695622-248Metallo-beta-lactamase type 2

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    248
  • Mass (Da)
    27,961
  • Last updated
    2000-10-01 v1
  • Checksum
    D340984E4D18059A
MKGLKGLLVLALGFTGLQVFGQQNPDIKIEKLKDNLYVYTTYNTFKGTKYAANAVYMVTDKGVVVIDSPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKLGAKTYSTKMTDSILAKENKPRAKYTFDNNKSFKVGKTEFQVYYPGKGHTADNVVVWFPKDKVLVGGCIVKSGDSKDLGFIGEAYVNDWTQSIHNIQQKFPDVQYVVAGHDDWKDQTSIQHTLDLISEYQQKQKASN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF189305
EMBL· GenBank· DDBJ
AAF89161.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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