Q9JXW7 · CRGA_NEIMB
- ProteinHTH-type transcriptional regulator CrgA
- GenecrgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids299 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Regulatory protein that activates transcription of mdaB, encoding a NADPH:quinone oxidoreductase, and represses its own transcription (PubMed:15866928).
Under the same experimental conditions, no regulation of transcription of pilus and capsule genes is detected (PubMed:15866928).
Under the same experimental conditions, no regulation of transcription of pilus and capsule genes is detected (PubMed:15866928).
Activity regulation
Activation and repression activities are enhanced by the addition of alpha-methylene-gamma-butyrolactone (MBL), an inducer of NADPH:quinone oxidoreductase.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 20-39 | H-T-H motif | ||||
Sequence: FSRAAEQLAMANSAVSRIVK |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHTH-type transcriptional regulator CrgA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionQ9JXW7
Proteomes
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 55 | Abolishes DNA binding. | ||||
Sequence: R → Q |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000458851 | 1-299 | HTH-type transcriptional regulator CrgA | |||
Sequence: MKTNSEELTVFVQVVESGSFSRAAEQLAMANSAVSRIVKRLEEKLGVNLLNRTTRQLSLTEEGAQYFRRAQRILQEMAAAETEMLAVHEIPQGVLSVDSAMPMVLHLLAPLAAKFNERYPHIRLSLVSSEGYINLIERKVDIALRAGELDDSGLRARHLFDSRFRVIASPEYLAKHGTPQSTEELAGHQCLGFTEPGSLNTWAVLDAQGNPYKISPHFTASSGEILRSLCLSGCGIVCLSDFLVDNDIAEGKLIPLLAEQTSDKTHPFNAVYYSDKAVNLRLRVFLDFLVEELGNNLCG |
Proteomic databases
Expression
Induction
Negatively autoregulated.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-60 | HTH lysR-type | ||||
Sequence: MKTNSEELTVFVQVVESGSFSRAAEQLAMANSAVSRIVKRLEEKLGVNLLNRTTRQLSLT |
Domain
Each subunit contains an N-terminal DNA-binding domain, connected via a long linker helix to a C-terminal regulatory domain.
Sequence similarities
Belongs to the LysR transcriptional regulatory family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)33,033
- Last updated2000-10-01 v1
- Checksum3CC589E8636EAA90
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE002098 EMBL· GenBank· DDBJ | AAF42190.1 EMBL· GenBank· DDBJ | Genomic DNA |