Q9JW60 · GUAA_NEIMA
- ProteinGMP synthase [glutamine-hydrolyzing]
- GeneguaA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids521 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the synthesis of GMP from XMP.
Catalytic activity
- XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H+
Pathway
Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 81 | Nucleophile | |||
Active site | 171 | ||||
Active site | 173 | ||||
Binding site | 225-231 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | GMP synthase activity | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGMP synthase [glutamine-hydrolyzing]
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionQ9JW60
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140151 | 1-521 | GMP synthase [glutamine-hydrolyzing] | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length521
- Mass (Da)57,730
- Last updated2000-10-01 v1
- MD5 Checksum1D2940C64D36EBB40BFCFDCD69CCE36A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL157959 EMBL· GenBank· DDBJ | CAM07811.1 EMBL· GenBank· DDBJ | Genomic DNA |